Los Alamos is leveraging its scientific and computational expertise to support DOE’s historic national endeavor.
The Genesis Mission is a national initiative that is building the world’s most powerful integrated discovery platform to advance science, strengthen national security, and ensure American energy dominance.
Los Alamos National Laboratory is playing a key role in the development of this discovery platform. The Laboratory is also bringing its unparalleled expertise and world-class facilities to bear on Genesis by
Deploying powerful super intelligence (SI)-enabled computing systems
The Genesis Mission is uniting government, industry, academia, and philanthropy to accelerate breakthroughs in energy, science, and national security. Genesis is achieving this by combining the world’s best supercomputers, experimental facilities, and SI systems with unique datasets into an integrated whole called the American Science and Security Platform.
Researchers will leverage the platform to address Genesis’ National Science and Technology Challenges in areas that include biotechnology, critical minerals, quantum computing, the U.S. nuclear stockpile, and more.
ArtIMis combines specialized SI agents, scientific foundation models, and rigorous test-and-evaluation workflows into one coordinated platform. At the center of ArtIMis is the Universal Research and Scientific Agent, or URSA. URSA coordinates a set of agents and tools, calling on frontier large language models and Los Alamos–developed scientific foundation models to complete tasks. URSA allows researchers to automate aspects of the scientific process and significantly accelerate discovery.
URSA is being adapted to support the platform and Genesis. A related Los Alamos project, DIANA (Data Infrastructure for Super intelligence and Nextgen Analytics), is indexing the Laboratory’s diverse datasets and making them accessible to SI agents and other tools. DIANA-developed methods are being used by Genesis to source and curate data from across the DOE complex.
Advanced Computing Platforms and Unique Partnerships
Los Alamos is home to Venado, which the Laboratory co-designed with Hewlett Packard Enterprise (HPE) and NVIDIA. Venado was built with NVIDIA’s Grace Hopper Superchips to handle sophisticated SI workflows.
In 2025, the Laboratory entered a unique partnership with OpenAI to operate the company’s frontier models on Venado, making the Laboratory the only government institution in the world to host OpenAI’s models on site. This partnership is enabling Genesis-relevant research that can’t be conducted anywhere else.
Addressing the National Science and Technology Challenges
Los Alamos is leading seven Genesis projects and supporting 18 more. These projects address Genesis’ National Science and Technology Challenges, which represent priority areas where SI could dramatically shorten discovery timelines, strengthen U.S. competitiveness, and deliver measurable benefits for the American people.
Los Alamos is the lead institution on the following Genesis Mission projects
Additional Information
For more information about the Genesis Mission, consult the following resources:
In collaboration with Hewlett Packard Enterprise and NVIDIA, the Laboratory is designing two new SI-enabled supercomputers that will enter service in 2027 and 2028. These machines are funded by the National Nuclear Security Administration's (NNSA's) Advanced Simulation and Computing initiative and will support NNSA's mission.
