RAPTER

Rapid Assessment of Platform Technologies to Expedite Response

Choosing the Right Vaccine Platform — Systematically.

RAPTER is an AI-enabled framework for outcome-driven vaccine platform selection, supporting rapid, evidence-based decision-making when new pathogens emerge.

Platform Choice Shapes Immune Outcomes

Even with the same antigen, different vaccine platforms generate distinct immune responses. Platform selection influences innate signaling, antigen presentation, durability, and immune memory. Yet outcome-relevant immune mechanisms remain poorly understood across platforms — making rapid, informed platform selection during emerging threats inherently difficult.

What RAPTER Does

RAPTER enables outcome-driven vaccine platform selection by integrating curated evidence, mechanistic modeling, and uncertainty-aware scoring to inform high-consequence decisions.

Validated Across Pathogens and Platforms

Validated across 16 pathogens and 11 vaccine platforms through a 19-member consortium spanning national laboratories, academia, and industry.

Improve Predictive Accuracy Through Data Collaboration

Contribute Published and Unpublished Vaccine Data

We welcome curated datasets, experimental results, and collaborative partnerships to strengthen predictive performance, refine outcome-specific modeling, and expand pathogen coverage.

We especially encourage submission of unpublished negative or null results. Accounting for studies with limited or absent protection reduces survivorship bias and improves the reliability of outcome-driven platform selection.

Program Sponsor

The RAPTER program is sponsored by the Joint Science Technology Office (JSTO), Defense Threat Reduction Agency (DTRA) under Award No. HDTRA1242031. Any opinions, findings, conclusions, or recommendations expressed on this site are those of the authors and do not necessarily reflect the views of the U.S. Government.