Los Alamos National Laboratory

Los Alamos National Laboratory

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Waveguide Biosensor

Rapid and sensitive detection of disease-associated biomarkers in an immunoassay format using a waveguide-based optical biosensor. 

LAUR: 16-22501


  • Self-assembled Monolayers- They are stable, specific, and robust silane-based surfaces used for waveguide functionalization that reduce nonspecific binding of biomarkers and enhance the signal detection.
  • Membrane Insertion- This approach utilizes the natural chemical interactions of an amphiphilic target with lipid bilayers thereby enabling them to partition into membrane mimetic surfaces.
  • Lipoprotein Capture- This exploits the association of lipid targets with lipoproteins to capture and detect lipid biomarkers.

R.M. Sakamuri, P. Capek, T.J. Dickerson, C.E. Barry III, H. Mukundan, and B.I. Swanson. “Detection of stealthy small amphiphilic biomarkers.” (2014). Journal of Microbiological Methods 103:112-117.

H. Mukundan, D.N. Price, M. Goertz, R. Parthasarathi, G.A. Montano, S. Kumar, M. Scholfield, A.S. Anderson, S. Gnanakaran, S. Iyer, J. Schmidt, and B.I. Swanson. “Understanding the interaction of Lipoarabinomannan with membrane mimetic architectures.” (2012). Tuberculosis 92: 38-47.


S-116289.001, U.S. Patent No. 8,859,268, entitled “Quantitative Multiplex Detection of Pathogen Biomarkers”, October 8th, 2009

S-121865.001, U.S. Non-Provisional Patent Application No. 13/529,847, entitled “Discovery, Detection and Use of Biomarkers”, June 21st, 2011

S-129617.001, U.S. Non-Provisional Patent Application No. 14/228,170, entitled “Biosensor Based on the Innate Immune System”, March 27th, 2014

Development Stage

TRL 8-9. The full system has been tested and successfully used in the real world environment.