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Closing the Mesoscale Gap Los Alamos proposes to fill in the gaps in our fundamental understanding of materials with MaRIE, a facility designed to gain access to the mesoscale. Los Alamos makes a bold proposal to understand and control material properties Cindy Bolme and Amy Clarke don’t see themselves as revolutionaries, and neither of them is talking about a revo- lution. They’re just helping to start one. The two Los Alamos scientists are contributing to a body of knowledge that, once integrated into the science- technology culture, is likely to revolutionize how we discover, develop, and apply new materials. Bolme’s work is the more explosive, with investigations into shock physics, high- pressure dynamics, and the behavior of materials under extreme conditions. Clarke wants anything but an explosion as she investigates how controlling fabrication and processing parameters can produce materials that behave as predicted. Bolme and Clarke are part of a group of early-career technical staff engaged in what Los Alamos physicist 2 1663 January 2015 Cris Barnes calls “science on the roadmap to MaRIE.” Not a lady but an acronym for Matter-Radiation Interactions in Extremes, MaRIE is the multi-purpose, billion-dollar materials research complex and user facility proposed for Los Alamos National Laboratory. MaRIE answers the mission need for an experimental facility that can accelerate the qualification, certification, and assessment of materials for national security and science solutions. A huge endeavor that would entail, at the very least, the construction of an electron accelerator, an x-ray free-electron laser, a diagnostic hall, and a materials fabri- cation facility, MaRIE would be separate from, but integrated with, existing Laboratory facilities and would eventually affect every program at the Lab in some way or another.