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Bioscience Division, B


  • Division Leader
    Jose A. Olivares
  • Deputy Division Leader
  • Chief of Staff
    Kathy Kelly
  • Executive Office Administrator
    Nicole Voight
  • Division Office
    505 667 2690

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Contact Information

(505) 667 2310
xie at lanl dot gov

Media Contact

B Div Communications
Rebecca McDonald
(505) 665-4650

Other Resources

Joint Genome Institute

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Gary Xie

Microbial Genome Annotation & Analysis

Gary Xie obtained his medical degree (B.M) from Xianya School of Medicine, Central South University (formerly Hunan Medical University) in China (1992). He received both the M.S. (1998) and Ph.D. degrees (2002) from the University of Florida (Gainesville, FL, USA). His Ph.D. studies focused on the comparative genome analysis of aromatic amino acid biosynthesis. He did postdoctoral research on the human chromosome and bacterial genome annotation and analysis at JGI-Los Alamos (2002-2004). Subsequently, he was appointed as a Technical Staff Member (TSM) at the bioscience division, Los Alamos National Laboratory. He currently is the Principal Investigator on a project to annotate and curate all oral pathogen genome sequences for the ORALGEN database. Dr. Xie has more than 10 years experience in field of microbial genome annotation and analysis, and is the instigator and head organizer for several national or international congresses and practical workshop courses, in conjunction with IADR/AADR annual conference. He has published over 40 peer-reviewed articles.

Research Interests

  • Metagenomics involving sequenced environmental samples
  • Development of bioinformatic applications for single genome/metagenome annotation and analysis
  • Comparative studies of human pathogens

Recent Publications

Xie G, Chain PSG, Lo CC, Liu KL, Gans J, Merritt J, and Qi F. Community and Gene Composition of a Human Dental Plaque Microbiota Obtained by Metagenomic Sequencing, Molecular Oral Microbiology, Vol 25, Issue 6, start page 391, 29 OCT 2010 | DOI: 10.1111/j.2041-1014.2010.00587.x

Klein MI, DeBaz L, Agidi S, Lee H, Xie G, Lin AH, Hamaker BR, Lemos JA, Koo H. Dynamics of Streptococcus mutans transcriptome in response to starch and sucrose during biofilm development. PLoS One. 2010 Oct 19;5(10):e13478. PMID: 20976057

Chen J, Xie G, Han S, Chertkov O, Sims D, Civerolo EL. Whole Genome Sequences of Two Xylella fastidiosa Strains (M12 and M23) Causing Almond Leaf Scorch Disease in California. J Bacteriol. 2010 Sep;192(17):4534. Epub 2010 Jul 2.PMID: 20601474

Nalbantoglu U, Sayood K, Dempsey MP, Iwen PC, Francesconi SC, Barabote RD, Xie G, Brettin TS, Hinrichs SH, Fey PD. Large direct repeats flank genomic rearrangements between a new clinical isolate of Francisella tularensis subsp. tularensis A1 and Schu S4. PLoS One. 2010 Feb 3;5(2):e9007.PMID: 20140244

Lo CC, C.A.Bonner, Xie G, M D'Souza and R.A.Jensen 2009 Cohesion-group Approach for Evolutionary Analysis of Aspartokinase, an Enzyme that Feed a Branched Network of Many Biochemical Pathways. Microbiol Mol Biol Rev. 2009 Dec;73(4):594-651.PMID: 19946135

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