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Norman Doggett

Norman Doggett received the Ph.D. degree in Experimental Pathology from the University of North Carolina at Chapel Hill in 1986. He was a Post Doctoral Fellow with Dr. Charles R. Cantor, in the Genetics Department at Columbia University from 1986-1989, where he became involved in human genome mapping.  He joined LANL in 1989 as a Staff Scientist in the Life Sciences Division and Center for Human Genome Studies.  Norman was Co-Investigator of the Chromosome 16 Mapping Program, funded by the U.S. Department of Energy, and served as the Human Genome Organization (HUGO) appointed Editor for Human Chromosome 16.  Norman was Deputy Center Leader of the Center for Human Genome Studies at LANL from Norman 1997 to 2002.  He has been a member of several collaborations involving positional cloning of disease genes on chromosome 16, including the International Batten Disease Consortium, the American Polycystic Kidney Disease Consortium, and the Familial Mediterranean Fever Consortium. 

After completion of the human genome project Norman focused his research efforts on bio-detection and bio-forensics programs funded by the Department of Homeland Security (DHS).  He currently is the Team Leader for Detection and Forensics and leads research projects on bioassay design and development against a wide range of bacterial and viral agents.  His team has developed over 160 real-time PCR detection assays in support of DHS funded projects.  These assays detect 22 pathogens, 10 antibiotic resistance genes and 11 toxin/virulence factors, and have been provided to the CDC and other agencies to support biosurveillance efforts.

Research Interests

  • Design and testing of detection and bioforensic assays for bacterial and viral pathogens.
  • Real-time gene expression studies in host-pathogen interactions.
  • Genomic studies of bacterial and viral pathogens.

Representative Publications

Smith, T.J.. Hill, K.K., Foley, B.T., Detter, J.C., Munk, A.C., Bruce, D.C., Doggett, N.A., Smith, L.A., Marks, J.D., Xie, G., and Brettin, T.S.  Analysis of the Neurotoxin Complex Genes in Clostridium botulinum subtype A1-A4 and B1 strains – BoNT/A3, BoNT/A4 and BoNT/B1 clusters are located within plasmids. PLoS ONE 2(12): e1271 (2007).

Challacombe J.F., Altherr M.R., Xie G., Bhotika S.S., Brown N., Bruce D., Campbell C.S., Campbell M.L., Chen J., Chertkov O., Cleland C., Dimitrijevic M., Doggett N.A., Fawcett J.J., Glavina T., Goodwin L.A., Green L.D., Han C.S., Hill K.K., Hitchcock P., Jackson P.J., Keim P., et al.  The complete genome sequence of Bacillus thuringiensis Al Hakam. J. Bacteriol. 189:3680-3681 (2007).

Linnemann, A.K., Platts, A.E., Doggett, N., Bode, J. and Krawetz, S.A.  Genome-wide identification of nuclear matrix attachment regions: An analysis of methods. Biochem Soc Trans. 35:612-617 (2007).

Cohen, S.M., Furey, T.S., Doggett, N.A., and Kaufman, D.G.  Genome-wide sequence and functional analysis of early replicating DNA in normal human fibroblasts. BMC Genomics 7:301 (2006).

Doggett, N.A., Xie, G., Meincke, L.J., Sutherland, R.D., Mundt, M.O., Berbari, N.S., Davy, B.E., Robinson, M.L., Rudd, M.K., Weber, J.L., Stallings, R.L., and Han, C.  A 360 Kb interchromosomal duplication of the Human HYDIN locus. Genomics 88:762-771 (2006).

Han, S., Xie, G., Challacombe, J.F., Altherr, M.R., Bhotika, S.S., Bruce, D., Campbell, C.S., Campbell, M.L., Chen, J., Chertkov, O., Cleland, C., Dimitrijevic, M., Doggett, N.A., Fawcett, J.J., Glavina, T., Goodwin, L.A., Hill, K.K., Hitchcock, P., Jackson, P.J., Keim, P. et al.  Pathogenomic sequence analysis of B. cereus and B. thuringiensis isolates closely related to Bacillus anthracis. J. Bacteriol. 188:3382-3390 (2006).

Martin, J., et al.  The sequence and analysis of duplication-rich human chromosome 16.  Nature 432:988-994 (2004).

International Human Genome Sequencing Consortium. Finishing the euchromatic sequence of the human genome.  Nature 431:931-945 (2004).

Watson, V., Doggett, N.A., Albertson, D.G., Andaya, A., Chinnaiyan, A., van Dekken, H., Ginzinger, D., Haqq, C., Jain, A., James, K., Kamkar, S., Kowbel, D., Pinkel, D., Schmitt, L., Simko, J., Volik, S., Weinberg, V., Paris, P.L. and Collins, C.  Integration of high resolution array comparative genomic hybridization analysis of chromosome 16q with expression array data refines common regions of loss at 16q23-qter and identifies underlying candidate tumor suppressor genes in prostate cancer.  Oncogene, 23:3487-3494 (2004).

So, C.-K., Nie, Y., Song, Y., Yang, G.-Y., Chen, S., Wei, C., Wang, L.-D., Doggett, N.A., and Yang, C.-S.  Loss of heterozygosity and internal tandem duplication mutations of the CBP gene are frequent events in human esophageal squamous cell carcinoma.  Clinical Cancer Research 10:19-27 (2004).

Powell, J., Gardner, A.E., Bais, A.J., Hinze, S., Kotchekova, M., Whitmore, S., Crawford, J., Spendlove, H., Doggett, N.A., Sutherland, G.R., Callen, D.F., and Kremmidiotis, G.  Sequencing, transcript identification and quantitative gene expression profiling in the breast cancer loss of heterozygosity region 16q24.3 reveals three potential tumour suppressor genes.  Genomics 80:303-310 (2002).

Aparicio, S., Chapman, J., Stupka, E., Putnam, N., Chia, J-M., Dehal, P., Christoffels, A., Rash, S., Hoon, S., Smit, A., Gelpke, MDS., Roach, J., Oh, T., Ho, IY., Wong, M., Detter, C., Verhoef, F., Predki, P., Tay, A., Lucas, S., Richardson, P., Smith, SF., Clark, MS., Edwards, Y.J.K., Doggett, N., Aharkikh, A., Tavtigian, S.V., Pruss, D., Barnstead, M., Evans, C., Baden, H., Powell, J., Glusman, G., Rowen, L., Hood, L., Tan, Y.H., Elgar, G., Hawkins, T., Venkatesh, B., Rokhsar, D., and Brenner S.  Whole-genome shotgun assembly and analysis of the genome of fugu rubripes.  Science 297:1301-1310 (2002).

Abdi, F., Bradbury, E.M., Doggett, N., and Chen, X.  Rapid characterization of DNA oligomers and identification of single nucleotide polymorphisms using nucleotide-specific mass tags.  Nucleic Acids Research 29:e61 (2001).

Han, C.S., Buckingham, J., Meincke, L.J., and Doggett N.A.  Vector for high-throughput sequencing: construction and preparation with cyclic cut-ligation.  Biotechniques 30:1208-1211 (2001).

Daniels, R.J., Peden, J.F., Lloyd, C.R., Horsley, S.W., Clark, K., Tufarelli, C., Kearney, L., Buckle, V.J., Doggett, N.A., Flint, J., and Higgs, D.R.  Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16.  Human Molecular Genetics 10:339-352 (2001).

International Human Genome Sequencing Consortium.  Initial sequencing and analysis of the human genome.  Nature 409:860-921 (2001).

The International Human Genome Mapping Consortium.  Nature 409:934-941 (2001).

Yu, A., Zhao, C., Fan, Y., Jang, W., Mungall, A.J., Deloukas, P., Olsen, A., Doggett, N.A., Ghebranious, N., Broman, K.W., and Weber.J.L.  Comparison of human genetic and sequence-based physical maps.  Nature 409:951-953 (2001).

The BAC Resource Consortium.  Integration of cytogenetic landmarks into the draft sequence of the human genome.  Nature 409:953-958 (2001).

Her, C., Wu, X.L., Bailey, S.M., and Doggett, N.A.  Mouse MutS homolog 4 is predominantly expressed in testis and interacts with MutS homolog 5.  Mammalian Genome, 12:73-76 (2001).

Pollock, D.D., Eisen, J.A., Doggett, N.A., and Cummings M.P.  A Case for evolutionary genomics and the comprehensive examination of sequence biodiversity.  Molecular Biology and Evolution 17:1776-1788 (2000).

Han, C.S., Jewett, P.B., Campbell, M.L., Meincke, L.J., Tesmer, J.G., Mundt, M.O., Sutherland, R.D., Kim, U.-J., Deaven, L.L., and Doggett, N.A.  Construction of a BAC contig map of chromosome 16q by two-dimensional overgo hybridization.  Genome Research. 10:714-721 (2000).

Cai, L., Struk, B., Adams, M.D., Ji, W., Haaf, T., Kang, H.-L., Dho, S.H., Xu, X., Ringpfeil, F., Nancarrow, J., Zäch, S., Schaen, L., Stumm, M., Niu, T., Chung, J., Lunze, K., Verrecchia, B., Goldsmith, L.A., Viljoen, D., Figuera, L.E., Fuchs, W., Lebwohl, M., Uitto, J., Richards, R., Hohl, D., Ramesar, R., Callen, D.F., Kim, U.-J., Doggett, N.A., Neldner, K.H., and Lindpainter, K.  A 500 Kb region on chromosome 16p13.1 contains the pseudoxanthoma elasticum locus: High resolution mapping and genomic structure.  Journal of Molecular Medicine, 78:36-46 (2000).

Brylawski, B.P., Cohen, S.M., Longmire, J.L., Doggett, N.A., Cordeiro-Stone, M., and Kaufman, D.G.  Construction and characterization of cosmid libraries of DNA replicated very early in the S phase of normal human fibroblasts.  Journal of Cellular Biochemistry 78:509-517 (2000).

Her, C., Wu, X., Wan, W., and Doggett, N.A.  Identification and characterization of the mouse MutS homologue 5: Msh5Mammalian Genome, 10:1054-1061 (1999).

Cao, Y., Kang, H.L., Xu, X., Wang, M., Dho, S.H., RyulHuh, J., Lee, B.-J., Kalush, F., Bocskai, D., Ding, Y., Tesmer, J.G., Lee, J., Moon, E., Jurecic, V., Baldini, A., Weier, H.-U., Doggett, N.A., Simon, M.I., Adams, M.D., and Kim, U.-J. A 12 Mbp complete coverage BAC contig map in human chromosome 16p13.1-11.2.  Genome Research 9:763-774 (1999).

Centola, M., Chen, X.G., Sood, R., Deng, Z.M., Aksentijevich, I., Blake, T., Ricke, D.O., Chen, X., Wood, G., Zaks, N., Richards, N., Krizman, D., Mansfield, E., Apostolou, S., Liu, J.M., Sharfran, N., Vendula, A., Hamon, M., Cercek, A., Kahan, T., Gumucio, D., Callen, D.F., Richards, R.I., Moyzis, R.K., Doggett, N.A., Collins, F.S., Liu, P.P., Fischel-Ghodsian, N., and Kastner, D.L.  Construction of an ~700-kb transcript map around the familial Mediterranean fever locus on human chromosome 16p13.3.  Genome Research 8:1172-1191 (1998).

Kouprina, N., Campbell, M., Graves, J., Campbell, E., Meincke, L., Tesmer, J., Grady, D.L., Doggett, N.A., Moyzis, R.K., Deaven, L.L., and Larionov, V.  Construction of human chromosome 16- and 5-specific circular YAC/BAC libraries by in-vivo recombination in yeast (TAR cloning).  Genomics 53:21-28 (1998).

Whitmore, S.A., Settasatian, C., Crawford, J., Lower, K.M., McCallum, B., Seshadri, R., Cornelisse, G.J., Moerland, E.W., Cleton-Jansen, A.-M., Tipping, A.J., Mathew, C.G., Savnio, M., Savoia, A., Verlander, P., Auerbach, A.D., Vanberkel, C., Pronk, J.C., Doggett, N.A., and Callen, D.F.  Characterization and screening for mutations of the growth-arrest-specific-11 (GAS11) and C16ORF3 genes at 16q24.3 in breast cancer.  Genomics 52:325-331 (1998).

Her, C, and Doggett, N.A.  Cloning, structural characterization, and chromosome localization of the human ortholog of Saccharomyces cerevisiae MSH5 gene.  Genomics 52:50-61 (1998).

Centra, M., Memeo, E., d’Apolito, M., Savino, M., Ianzano, L., Notarangelo, A., Liu, J.M., Doggett, N.A., Zelante, L., and Savoia, A.  Fine exon-intron structure of the Fanconi anemia group A (FAA) gene and characterization of two genomic deletions.  Genomics 51:463-467 (1998).

Kuss, B.J., O’Neil, G.M., Eyre, H., Doggett, N.A., Callen, D.F., and Davey, R.A.  ARA, a novel ABC transporter, is located at 16p13.1, is deleted in inv(16) leukaemias, and is shown to be expressed in primative hematapoietic precursors.  Genomics 51:455-458 (1998).

Whitmore, S.A., Crawford, J., Apostolou, S., Eyre, H., Baker, E., Lower, K.M., Settasatian, C., Goldup, S., Seshadri, R., Gibson, R.A., Mathew, C.G., Cleton-Jansen, A.-M., Savoia, A., Pronk, J.C., Auerbach, A.D., Doggett, N.A., Sutherland, G.R., and Callen, D.F.  Construction of a high-resolution physical and transcription map of chromosome 16q24.3:  A region of frequent loss of heterozygosity in sporadic breast cancer.  Genomics 50:1-8 (1998).

Filippova, G.N., Lindblom, A., Meincke, L.J., Klenova, E.M., Neiman, P.E., Collins, S.J., Doggett, N.A., and Lobanenkov, V.V.  A widely expressed transcription factor with multiple DNA-sequence specificity, CTCF, is localized at chromosome segment 16q22.1 within one of the smallest regions of overlap for common deletions in breast and prostate cancers.  Genes, Chromosomes and Cancer 22:26-36 (1998).

Hiraguri, S., Godfrey, T., Nakamura, H., Graff, J., Collins, C., Shayesteh, L., Doggett, N., Johnson, K., Wheelock, M., Herman, J., Baylin, S., Pinkel, D., and Gray, J.  Mechanisms of inactivation of E-cadherin in breast cancer cell lines.  Cancer Research. 58:1972-1977 (1998).

Levran, O., Doggett, N.A., and Auerbach, A.D.  Identification of Alu mediated deletions in patients with Fanconi anemia.  Human Mutation 12:145-152 (1998).

The International FMF Consortium: Aksentijevich, I., Centola, M., Deng, Z., Sood, R., Balow, Jr., J.E., Wood, G., Zaks, N., Mansfield, E., Raben, N., Eisberg, S., Pras, E., Pras, M., and Kastner, D.L.; Blake, T., Baxevanis, A., Collins, F.S., and Liu, P.P.; Chen, X., Shohat, M., Rotter, J.I., and Fischel-Ghodsian, N.; Richards, N., Shelton, D.A., and Gumucio, D.L.; Yokoyama, Y., Mangelsdorf, M., Orsborn, A., and Richards, R.I.; Ricke, D.O., Buckingham, J.M., Moyzis, R.K., Deaven, L.L., and Doggett, N.A.  Ancient missense mutations in a new member of the RoREt gene family cause familial Mediterranean fever.  Cell 90:797-807 (1997).

Rowley, J.D., Reshmi, S., Sobulo, O., Musvee, T., Anastasi, J., Raimondi, S., Schneider, N.R., Barredo, J.C., Schlegelberger, B., Behm, F., Doggett, N.A., Borrow, J., and Zeleznik-Le, N.  All patients with the t(11;16)(q23;p13.3) which involves MLL and CBP have treatment-related hematological disorders.  Blood 90:535-541 (1997).

Sobulo, O.M., Borrow, J., Tomek, R., Reshmi, S., Harden, A., Schlegelberger, B., Housman, D., Doggett, N.A., Rowley, J.D., and Zeleznik-Le, N.  Mll is fused to CBP, a histone acetyltransferase, in therapy-related acute myeloid leukaemia with a t(11;16)(q23;p13.3).  Proc. Natl. Acad. Sci. USA. 94:8732-8737 (1997).

Eichler, E.E., Budarf, M., Rocchi, M., Deaven, L.L., Doggett, N.A., Baldini, A., Nelson, D.L., and Mohrenweiser, H.W.  Interchromosomal duplications of the Adrenoleukodystrophy locus: A phenomenon of pericentromeric plasticity.  Human Molecular Genetics 6:991-1002 (1997).

Giles, R.H., Petrij, F., Dauwerse, H.G., den Hollander, A.I., Lushnikova, T., van Ommen, G.-J., Goodman, R.H., Deaven, L.L., Doggett, N.A., Peters, D.J.M., and Breuning, M.H.  Construction of a 1.2 Mb contig surrounding, and molecular analysis of the human CREB-binding protein (CBP) gene on Chromosome 16p13.3. Genomics 42:96-114 (1997).

Sood, R., Blake, T., Aksentijevich, I., Wood, G., Chen, X., Gardner, D., Shelton, D.A., Mangelsdorf, M., Orsborn, A., Pras, E., Balow, Jr., J.E., Centola, M., Deng, Z., Zaks, N., Chen, X., Richards, N., Fischel-Ghodsian, N., Rotter, J.I., Pras, M., Shohat, M., Deaven, L.L., Gumucio, D.L., Callen, D.F., Richards, R.I., Collins, F.S., Liu, P., Kastner, D.L., and Doggett, N.A.  Construction of a 1-Mb restriction-mapped cosmid contig containing the candidate region for the familial Mediterranean fever locus (MEFV) on 16p13.3.  Genomics 42:83-95 (1997).

Mitchison, H.M., Taschner, P.E.M., Kremmidiotis, G., Callen, D.F., Doggett, N.A., Lerner, T.J., Janes, R.B., Wallace, B.A., Munooe, P.B., O’Rawe, A.M., Gardiner, R.M., and Mole, S.E.  Structure of the CLN3 gene and predicted structure, location and function of the CLN3 protein.  Neuropaediatrics  28:12-14 (1997).

Ianzano, L., d’Apolito, M., Centra, M., Savino, M., Levran, O., Auerbach, A.D., Clenton-Jansen, A.-M., Doggett, N.A., Pronk, J., Tipping, A.J., Gibson, R.A., Mathew, C.G., Whitmore, S.A., Apostolou, S., Callen, D.F., Zelante, L., and Savoia, A.  The genomic organization of the Fanconi anaemia group A (FAA) gene.  Genomics 41:309-314 (1997).

Mitchison, H.M., Munroe, P.B., O’Rawe, A.M., Taschner, P.E.M., de Vos, N., Kremmidiotis, G., Lensink, I., Munk, C.A., D’Arigo, K.L., Anderson, J.W., Lerner, T.J., Moyzis, R.K., Callen, D.F., Breuning, M.H., Doggett, N.A., Gardiner, R.M., and Mole, S.E.  Genomic structure and complete nucleotide sequence of the Batten disease gene, CLN3.  Genomics 40:346-350 (1997).

Flint, J., Thomas, K., Micklem, G., Raynham, H., Clark, K., Doggett, N.A., King, A., and Higgs, D.R.  The relationship between chromosome structure and function at a human telomeric region.  Nature Genetics 15:252-257 (1997).

Yu, S., Mangelsdorf, M., Duncan, H., Hobson, L., Baker, E., Eyre, H., Lapsys, N., Lane, S., LePaslier, D., Doggett, N.A., Sutherland G.R., and Richards, R.I.  Distamycin A - sensitive chromosomal fragile site FRA16B is an amplified 33 base pair AT-rich minisatellite repeat. Cell 88:367-374 (1997).

The Fanconi anaemia/Breast Cancer Consortium: Apostolou, S., Whitmore, S.A., Crawford, J., Lennon, G., Sutherland, G.R., and Callen, D.F.; Ianzano, L., Savino, M., D’Apolito, M., Notarangelo, A., Meneo, E., Piemontese, M.R., Zelante, L., and Savoia, A.; Gibson, R.A., Tipping, A.J., Morgan, N.V., Hassock, S., Jansen, S., de Ravel, T.J., Van Berkel, C., Pronk, J., Easton, D.F., and Mathew, C.G.; Clenton-Jansen, A.-M., Moerland, E.W., and Cornelisse, C.J.; Doggett, N.A., Deaven, L.L., and Moyzis, R.K.  Positional cloning of the Fanconi anaemia group A gene.  Nature Genetics 14:324-328 (1996).

Eichler, E.E., Lu, F., Shen, Y., Antonucci, R., Jurecic, V., Doggett, N.A., Moyzis, R.K., Baldini, A., Gibbs, R.A., and Nelson, D.L.  Duplication of a gene-rich cluster between 16p11.1 and Xq28: A novel pericentromeric-directed mechanism for paralogous genome evolution.  Human Molecular Genetics 5:899-912 (1996).

Dackowski, W.R., Connors, T.D., Bowe, A., Stanton, V., Housman, D., Doggett, N.A., Landes, G.M., and Klinger, K.W.  The region surrounding the PKD1 gene: A 700-kb P1 contig from a YAC-deficient interval.  Genome Research 6:515-524 (1996).

Doggett, N.A., Goodwin, L.A., Tesmer, J.G., Meincke, L.J., Bruce, D.C., Clark, L.M., Altherr, M.R., Ford, A.A., Chi, H.-C., Marrone, B.L., Longmire, J.L., Lane, S.A., Whitmore, S.A., Lowenstein, M.G., Sutherland, R.D., Mundt, M.O., Knill, E.H., Bruno, W.J., Macken, C.A., Torney, D.C., Wu, J.R., Griffith, J., Sutherland, G.R., Deaven, L.L., Callen, D.F., and Moyzis R.K.  An integrated physical map of human chromosome 16.  Nature 377:Suppl:335-365 (1995).

The International Batten Disease Consortium: Lerner, T.J., Boustany, R.-M.N., Anderson, J.W., D’Arigo, K.L., Schlumpf, K., Buckler, A.J., Gusella, J.F., and Haines, J.L.; Kremmidiotis, G., Lensink, I.L., Sutherland, G.R., and Callen, D.F.; Taschner, P.E.M., de Vos, N., van Ommen, G.-J.B. and Breuning M.H.; Doggett, N.A., Meincke, L.J., Liu, Z.-Y., Goodwin, L.A., and Tesmer, J.G.; Mitchison, H.M., O’Rawe, A., Munroe, P.B., Järvelä, I.E., Gardiner, R.M., and Mole, S.E.  Isolation of a novel gene underlying Batten disease, CLN3.  Cell 82:949-957 (1995).

Callen, D.F., Lane, S.A., Kozman, H., Kremmidiotis, G., Whitmore, S.A., Lowenstein, M., Doggett, N.A., Kenmochi, N., Page, D.C., Maglott, D.R., Nierman, W.C., Murakawa, K., Berry, R., Sikela, J.M., Houlgatte, R., Auffray, C., and Sutherland, G.R.  Integration of transcript and genetic maps of chromosome 16 at near 1 Mb resolution: Demonstration of a 'hot-spot' for recombination at 16p12.  Genomics 29:503-511 (1995).

Järvelä, I.E., Mitchison, H.M., O'Rawe, A.M., Taschner, P.E.M., de Vos, N., Lerner, T.J., D'Arigo, K.L., Callen, D.F., Thompson, A.D., Knight, M., Marrone, B.L., Mundt, M.O., Meincke, L., Breuning, M.H., Gardiner, R.M., Doggett, N.A., and Mole, S.E.  YAC and cosmid contigs spanning the Batten disease region (CLN3) at 16p12.1-p11.2.  Genomics 29:478-489 (1995).

The AMERICAN PKD1 Consortium: Burn, T.C., Connors, T.D., Dackowski, W.R., Petry, L.R., Van Raay, T.J., Millholland, J.M., Venet, M., Miller, G., Hakim, R.M., Landes, G.M., and Klinger, K.W.; Qian, F., Onuchic, L.F., Watnick, T., and Germino, G.G.; Doggett, N.A.  Analysis of the genomic sequence for the autosomal dominant polycystic kidney diesase (PKD1) gene predicts the presence of a leucine-rich repeat.  Human Molecular Genetics 4:575-582 (1995).

Taschner, P.E.M., De Vos, N., Thompson, A.D., Callen, D.F., Mole, S.E., Dooley, T.P., Doggett, N.A., Barth, P.G., and Breuning, M.H.  Chromosome 16 microdeletion in a patient with juvenile neuronal ceroid lipofuscinosis (Batten disease).  American Journal of Human Genetics 56:663-668 (1995).

Bruno, W.J., Knill, E., Balding, D.J., Bruce, D.C., Doggett, N.A., Sawhill, W.W., Stallings, R.L., Whittaker, C.C., and Torney, D.C.  Efficient pooling designs for library screening.  Genomics 26:21-30 (1995).

Shen, Y., Kozman, H.M., Thompson, A., Phillips, H.A., Holman, K., Nancarrow, J., Lane, S., Chen, Z.L., Apostolou, S., Doggett, N.A., Callen, D.F., Mulley, J.C., Sutherland, G.R., and Richards, R.I.  A PCR-based genetic linkage map of human chromosome 16.  Genomics 22:68-76 (1994).

Okumura, K., Stallings, R.L., Doggett, N.A., and Ward, D.C.  In situ hybridization mapping of human chromosome 16: Evidence for a high frequency of repetitive DNA sequences.  Cytogenetics and Cell Genetics 67:61-67 (1994).

Nancarrow, J.K., Kremer, E., Baker, E., Holman, K., Eyre, H., Doggett, N.A., Le Paslier, D., Callen, D.F., Sutherland, G.R., and Richards, R.I.  Implications of FRA16A structure for the mechanism of chromosomal fragile site genesis.  Science 264:1938-1941 (1994).

Doggett, N.A., Callen, D.F., Cheng, Z.L., Moore, S., Tesmer, J., Duesing, L., and Stallings, R.L.  Identification and regional localization of a human IMP dehydrogenase-like locus (IMPDHL1) at 16p13.13.  Genomics 18:687-689 (1993).

Stallings, R.L., Whitmore, S.A., Doggett, N.A., and Callen, D. F.  Refined physical mapping of chromosome 16 low abundance repetitive DNA sequences.  Cytogenetics and Cell Genetics 63:97-101 (1993).

Callen, D.F., Doggett, N.A., Stallings, R.L., Chen, L.Z., Whitmore, S.A., Lane, S.A., Nancarrow, J.K., Apostolou, S., Thompson, A.D., Lapsys, N.M., Eyre, H.J., Baker, E.G., Shen, Y., Richards, R.I., Holman, K., Phillips, H. and Sutherland, G.R.  High resolution cytogenetic-based physical map of human chromosome 16.  Genomics 13:1178-1185 (1992).

Stallings, R.L., Doggett, N.A., Callen, D., Apostolou, S., Chen, L.Z., Nancarrow, J.K., Whitmore, S.A., Harris, P., Michison, H., Breuning, M., Sarich, J., Fickett, J., Cinkosky, M., Torney, D.C., Hildebrand, C.E. and Moyzis, R.K.  Evaluation of a cosmid contig physical map of human chromosome 16.  Genomics 13:1031-1039 (1992).

Stallings, R.L., Doggett, N.A., Okumura, K., and Ward, D.  Chromosome 16 specific repetitive DNA sequences that map to chromosome regions known to undergo breakage/rearrange-ment in leukemia cells.  Genomics 13:332-338 (1992).

Doggett, N.A., Smith, C.L., and Cantor, C.R.  The effect of DNA concentration on electrophoretic mobility in pulsed field gels.  Nucleic Acids Research 20:859-864 (1992).

Narayanswami, S., Doggett, N.A., Hildebrand, C.E., Clark, L.M., and Hamkalo, B.A.  Cytological and molecular characterization of centromeres in Mus domesticus and mus spretus.  Mammalian Genome 2:186-194 (1992).

Stallings, R.L., Torney, D.C., Hildebrand, C.E., Longmire, J.L., Deaven, L.L., Jett, J.H., Doggett, N.A., and Moyzis, R.K.  Physical mapping of human chromosomes by repetitive sequence fingerprinting.  Proc. Natl. Acad. Sci. USA. 87:6218-6222 (1990).

Doggett, N.A., Chen, J.-F., Smith, C.L., and Cantor, C.R.  The Huntington disease gene is most likely within 325 kb of the telomere of chromosome 4.  Proc. Natl. Acad. Sci. USA. 86:10011-10014 (1989).

Doggett, N.A., Cordeiro-Stone, M., Chae, C.-B., and Kaufman, D.G.  Timing of proto-oncogene replication: A possible determinant of early S phase sensitivity of C3H 10T1/2 cells to transformation by chemical carcinogens.  Molecular Carcinogenesis 1:41-49 (1988).


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