Group Contacts
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Flow Cytometry and Green Flourescent Protein Reporter are Some Innovations Developed in B-9The Advanced Measurement Science Group is focused on the development of new instrumentation, techniques and biomolecules for a wide array of biomedical applications, from biothreat agent detection to protein structure determination to cancer diagnostics. The Group is divided into three teams focused on ligand development, optical instrumentation and structural biology. This group houses the Los Alamos Molecular Recognition Alliance, which develops novel affinity reagents in collaboration with three other Divisions at LANL. This Group also incorporates the National Flow Cytometry Resource (NFCR), which focuses on developing advanced flow cytometry instrumentation and applications, as well as facilitating their transfer to the biomedical community. Finally, the High-Throughput Gene Cloning and Protein Production Facility, which provides materials and innovative strategies for deciphering protein structure and function in collaboration with the TB Structural Genomics Consortium and the Integrated Center for Structure and Function Innovation are also a part of B-9. What's New?Flow Cytometry
Helper Plasmid Display Technology LicensedThe German company MorphoSys acquired a full license for the use of “helper plasmid display technology” developed in B Division’s Advanced Measurement Science Group. Andrew Bradbury (B-9) and his team developed the helper plasmid technology in 2006, to aid in antibody screening by simplifying the process and eliminating the need for helper phage (short for bacteriophage). Read More... |
B-9 Teams
Focus on ResearchLinks / Resources |
B-9 acting Group Leader Babs Marrone authored a feature story on flow cytometry that was published in the June 2009 issue of the Journal of the Association for Laboratory Automation. “Flow Cytometry: A Multipurpose Technology for a Wide Spectrum of Global Biosecurity Applications” examines how flow cytometry evolved over the last 40 years after being first developed at LANL, and how it could be more widely used for biosecurity and public health applications. Flow cytometry, and its offspring - flow sorting, are extremely useful technologies for biosecurity and public health studies related to infectious disease. Applications range from environmental surveillance of pathogens to diagnosis and the development of vaccines and therapeutics for prevention and control of infectious diseases. Flow cytometers have been developed for laboratory analysis and field deployment.