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Phone (505) 667-4912

Paul S. White

Scott White

Capabilities

  • Biosciences
  • Human genome
  • Flow cytometry
  • Biosecurity
  • Pathogen studies
  • Strategies for disease surveillance and management
  • Biological threat identification, characterization, detection/diagnosis,
  • Biological countermeasure
  • Transcriptomics
  • Next generation genome sequencing
  • Metagenomic
  • Influenza Sequence Database
  • Pandemic preparedness
  • Agricultural and zoonotic diseases
  • Integrated biosensors
  • Chemical Science
  • High Throughput Laboratory Network (HTLN)
  • Materials
  • Electron microscopy
  • Nuclear Engineering and Technology
  • Nonproliferation
  • Science of Signatures - Remote and Standoff Sensing
  • Ground-based sensing and sensors
  • Science of Signatures - In Situ Measurements
  • Electron microscopy

Expertise

Genomics - Development of tools for discovery and application of genetic variation. Technology development for rapid multiplex genotyping and detection.

Agriculture - Genomics tools applied to improvement of agriculture and food safety. Agricultural Risk Assessment. Plant pathogen detection and characterization.

Cooperative Threat Reduction - DOE GIPP collaboration with foreign bioscientists to develop improved poultry and wildlife screening for avian influenza. Microbial metagenome and metatranscriptome analysis of soils from contaminated sites.

Education

B.S, Biology, Texas Tech University, Lubbock, TX, 1984

Ph.D., Molecular Biology, Texas Tech University, Lubbock, TX,  1992

Postdoc, Plant Molecular Virology, The Samuel Roberts Noble Foundation, Ardmore, OK, 1992 - 1995

Postdoc, Genomics, R&D, Los Alamos National Laboratory, Los Alamos, NM, 1995 - 1998

 

LANL Positions

Scientist, Bioscience Division, Los Alamos National Laboratory, 2000 - present

Acting Deputy Division Leader, Bioscience Division, Los Alamos National Laboratory, 2010

Acting Program Manager, Chemical, Biological, and Medical Countermeasures, Homeland Security Program Office, Los Alamos National Laboratory, 2009 - 2010

Team Leader, Global Biosecurity and Applications Team, Biosecurity and Public Health Group, Bioscience Division, Los Alamos National Laboratory, 2007 - 2012

Technical Staff Member, Life Science Division, Los Alamos National Laboratory, 1998 - 2000

 

Professional Societies

National Citrus Strategic Planning Group member, 2010 (ongoing)

 

Awards

Los Alamos Award ,1998. DNA Sequence Finishing Team

Adjunct Asst. Professor, Cell and Molecular Biology, University of New Mexico School of Medicine, 1/1/99

Co-organizer, 3rd International Meeting on Single Nucleotide Polymorphism and Complex Genome Analysis, Taos, NM, 9/8/200

Defense Programs Award of Excellence 2000, Beryllium disease genetic assays, 2000

ENERGY 100 Award, Flow Cytomery, Flow Cytometry Resource Team, 2001

American Academy of Microbiology Critical Issues Colloquium participant: “Microbial Forensics: a Scientific Assessment”. Burlington, VT, 6/7/2002

NIH Biotechnology (SSS-Y and GGG-J) study section participant, 2003 - present

NNSA Pollution Prevention Award, Best in Class, Formamide replacement in genetic sequencing, 4/14/2004

LANL Pollution Prevention Award, Formamide replacement in genetic sequencing, 4/29/2004

LANL Distinguished Performance Award, Small Team, “Biological Risk Assessment”, CY 2004.

Adjunct Asst. Professor, Dept. Biological Sciences, New Mexico State University, 9/2005

BEST – Biological Emergency Support Team, 2006 – 2010

National Citrus Strategic Planning Group member, 2010 (ongoing)

 

Patents

DNA polymorphism identity determination by flow cytometry. United States Patent No. 6,287,766, 9/11/2001

Nucleic Acid Sequence Detection Using Multiplexed Oligonucleotide PCR. US Patent No. 7,153,656, 12/26/2006

DNA polymorphism identity determination using flow cytometry. European Patent Application EP2034031, 3/11/2009

 

Publications

Densmore, LD and PS White. The systematics and evolution of the Crocodilia as suggested by restriction endonuclease analysis of mitochondrial and nuclear ribosomal DNA, Copeia, 91:602-615. (1991).

White, PS and LD Densmore. Mitochondrial DNA. In Molecular Genetic Analysis of Populations: A Practical Approach. (A. R. Hoelzel, ed), IRL Press, Oxford. (1992).

White, PS, ML Gilbert, HT Nguyen, and RA Vierling. Maximum parsimony accurately reconstructs relationships of elite sorghum lines. Crop Science, 35:1560-1565. (1995).

White, PS, F Morales, and MJ Roossinck. Interspecific reassortment of genomic segments in the evolution of the cucumoviruses. Virology 207:334-337. (1995).

Dunbar, J, S White, and L Forney. Genetic diversity through the looking-glass: effect of enrichment bias. Applied and Environmental Microbiology 63:1326-1331. (1997).

Roossinck, MJ and PS White. Cucumovirus isolation and RNA purification. In Methods in Molecular Biology Vol. 81: Plant Virology Protocols: From Virus Isolation to Transgenic Resistance (G.D. Foster and S. Taylor, ed) The Humana Press, Inc.,Totowa, New Jersey., pp. 189-196. (1998).

White, PS, OL Tatum, H Tegelstrom, and LD Densmore. Mitochondrial DNA isolation and analysis. In Molecular Genetic Analysis of Populations: A Practical Approach, 2nd ed. (A. R. Hoelzel, ed), IRL Press, Oxford pp. 65-101. (1998).

Cai, H, K Kommander, PS White, and JP Nolan. Flow Cytometry-Based Hybridization and Polymorphism Analysis. SPIE Proceedings 3256:171-176. (1998).

Wang, Z, PS White, M Petrovic, OL Tatum, LS Newman, LA Maier, and BL Marrone. Differential susceptibilities to chronic beryllium disease contributed by different GLU69 HLA-DPB1 alleles. Journal of Immunology. 163:1647-1653. (1999).

White, PS, OL Tatum, LL Deaven, and JL Longmire. New male-specific tetranucleotide microsatellite markers from human Y chromosome. Genomics. 57(3):433-437. (1999).

Cai, H, PS White, DC Torney, A Deshpande, Z Wang, BL Marrone, and JP Nolan. Flow cytometry-based minisequencing: a new platform for high throughput single nucleotide polymorphism analysis. Genomics 66(2):135-143. (2000).

Rykov, VV, AJ Macula, CM Korzelius, DC Englehart, DC Torney and PS White. DNA sequences constructed on the basis of quaternary cyclic codes. Proc. 4th World Multiconference on Systematics, Cybernetics, and Informatics, SCI 2000/ISAS 2000. (2000).

Ray, DA, PS White, HV Duong, T Cullen, and LD Densmore Osteolaemus tetraspis: One species or two? In Crocodilian Biology and Evolution. (G. Grigg and C. Franklin, ed) Surrey Beatty & Sons, Publishers and Printers NSW, Australia. (2000).

White, PS and LD Densmore III. DNA sequence alignments and data analysis methods: their effect on the recovery of crocodilian relationships. In Crocodilian Biology and Evolution. (G. Grigg and C. Franklin, ed) Surrey Beatty & Sons, Publishers and Printers NSW, Australia. (2000).

International Human Genome Sequencing Consortium. Initial sequencing and analysis of the human genome. Nature. 409:860-921. (2001).

White, PS, P Kwok, P Oefner, and AJ Brookes. Meeting Report: 3rd International Meeting on Single Nucleotide Polymorphism and Complex Genome Analysis. SNPs : ‘Some Notable Progress’. European Journal of Human Genetics 9.4:316-318. (2001).

Brookes, AJ, PY Kwok, PS White, and PJ Oefner. SNiPpets from the Third International Meeting on Single Nucleotide Polymorphism and Complex Genome Analysis, September 8-11, 2000, Taos, New Mexico, USA. Human Mutation;; v.17(4):241-242. (2001).

Longmire, JL, JL Roach, M Maltbie, PS White, OL Tatum, and KD Makova. Tetranucleotide microsatellite markers for the Brown-headed Cowbird Molothrus ater. Journal of Avian Biology 31:76-78. (2001).

Diehl, S and PS White. Meeting Highlights. Cambridge Healthtech Institute’s Third Annual Conference on Human Genetic Variation. Pharmacogenomics. 2:79-84. (2001).

Nolan, JP, PS White, H Cai. SNP scoring for drug discovery applications. In, Integrated Drug Discovery Technologies (H.-Y. Mei and A. Czarnik, eds), Marcel Dekker. (2002).

Green LD, H Cai, DC Torney, DJ Wood, FJ Uribe-Romeo, L Kaderali, JP Nolan, and PS White. High-throughput SNP Scoring with GAMMArrays: Genomic Analysis using Multiplexed Microsphere Arrays. Progress in Biomedical Optics and Imaging. Biomedical Nanotechnology Architectures and Applications. Proceedings of SPIE, v. 4626:308-315. (2002).

Nolan J, L Gallegos, R Nolan, S Graves, H Cai, PS White. Molecular microbiology: Detection and identification of bacterial and viral pathogens. Cytometry (2002) suppl.11, p.27-28 (2002).

Kaderali L, A Deshpande, JP Nolan and PS White. Primer-design for multiplexed genotyping. Nucleic Acids Research. v. 31(6):1796-1802. (2003).

Keim, P, et al., “Microbial Forensics: a Scientific Assessment” American Academy of Microbiology Critical Issues Colloquium. Burlington, VT. 7-9 June 2002. (2003).

D’yachkov, AG, PL Erdös, AJ Macula, VV Rykov, DC Torney, C-S Tung, PA Vilenkin, and PS White. Exordium for DNA codes. Journal of Combinatorial Optimization, v. 7(4):369-379. (2004).

Knight, A, LA Zhivotovsky, DH Kass, DE Litwink, LD Green, PS White, and JL Mountain. Molecular, forensic and haplotypic inconsistencies regarding the identity of the Ekaterinburg remains. Annals of Human Biology. v. 31(2):129-138. (2004).

O’Donoghue, K, B Lomniczi, B McFerran, TJ Connor, B Seal, D King, J Banks, R Manvell, PS White, K Richmond, P Jackson, and M Hugh-Jones. Retrospective characterization of Newcastle Disease Virus Antrim ’73 in relation to other epidemics, past and present. Epidemiol. Infect. v. 132(2):357-368. (2004).

Cleland, C, PS White, A Deshpande, M Wolinsky, J Song, and JP Nolan. Development of Rationally Designed Nucleic Acid Signatures for Microbial Pathogens. Expert Reviews of Medical Diagnostics. v. 4(3):303-315. (2004).

Knight, A, LA Zhivotovsky, DH Kass, DE Litwin, LD Green, PS White. Richard Stone's news story "Buried, recovered, lost again? Response. Science. v. 306(5695):409-410. (2004).

Gallagher, KG, BG Milligan, and PS White. Isolation and characterization of microsatellite DNA loci in Aquilegia sp. Molecular Ecology Notes; v. 4(4):686-688. (2004).

Martin, J, C Han, LA Gordon, A Terry, S Prabhakar, XW She, G Xie, U Hellsten, YM Chan, M Altherr, et. al. The sequence and analysis of duplication-rich human chromosome 16. Nature. v.432(7020):988-994. (2004).

Deshpande, A, JP Nolan, PS White, YE Valdez, WC Hunt, CL Peyton, and CM Wheeler. TNF alpha promotor polymorphisms and susceptibility to HPV16-associated cervical cancer. Journal of Infectious Diseases; v.191(6):969-976. (2005).

D'yachkov, AG, PA Vilenkin, IK Ismagilov, RS Sarbaev, A Macula, D Torney, and S White. On DNA Codes. Problems of Information Transmission. v. 41(4):349-367. (2005).

Song, J, Y Xu, S White, KWP Miller, and M Wolinsky. SNPsFinder - a web-based application for genome-wide discovery of single nucleotide polymorphisms in microbial genomes. Bioinformatics. v.21(9):2083-2084. (2005).

D’yachkov, DC Torney, PA Vilenkin, and PS White. Reverse-Complement Similarity Codes. Electronic Notes in Discrete Mathematics. v.21 suppliment: complete. 281-282. (2005).

McAliley, LR, RE Willis, DA Ray, PS White, DA Brochu, and LD Densmore. Are crocodiles really monophyletic? – Evidence for subdivisions from sequence and morphological data. Molecular Phylogenetics and Evolution. v. 39(1):16-32. (2006).

Jacob A. Mark, Lance D. Green, Alina Deshpande, and P. Scott White. System Integration and Development for Biological Warfare Agent Surveillance. Proc. of SPIE Vol. 6540 65401D-9, (2007).

Deshpande A., J Gans, SW Graves, L Green, L Taylor, HB Kim, YA Kunde, PM Leonard, PE Li, J Mark, J Song, M Vuyisich, and PS White. A Rapid Multiplex Assay for Nucleic Acid-Based Diagnostics. Journal of Microbiological Methods, 80(2):155-163, 2010

Song, J, Po-E Li, Jason Gans, Momchilo Vuyisich, Alina Deshpande, Murray Wolinsky, and P. Scott White.  Simultaneous Pathogen Detection and Antibiotic Resistance Characterization Using SNP-Based Multiplexed Oligonucleotide Ligation-PCR (MOL-PCR). In: Advances in Experimental Medicine and Biology: Advances in Computational Biology. Springer (2010).

Deshpande, A and PS White. Multiplexed Nucleic Acid-based Assays for Molecular Diagnostics of Human Disease. Expert Review of Molecular Diagnostics 12(6):645–659 (2012).