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Norman A. Doggett

Norman Doggett

Capabilities

  • Biosciences
  • Human genome
  • Biosecurity
  • Pre-symptomatic diagnosis of infection,
  • Pathogen studies
  • Biological threat identification, characterization, detection/diagnosis,
  • Transcriptomics
  • Next generation genome sequencing
  • Single cell genomics
  • Genome annotation
  • Agricultural and zoonotic diseases
  • Information Science and Technology
  • Biological systems

Expertise

Genomics

Biosurveillance

Biodetection and Bioforensics

Quantitative PCR

Bioinformatics

Education

Ph.D., Experimental Pathology, University of North Carolina at Chapel Hill, 1986

B.A., Chemistry, North Carolina State University, 1980

 

LANL Positions

Team Leader, Bioscience Division, 2007 – present

Host and Pathogen Biology Team, 2007 - 2009
Biodetection and Bioforensics Team, 2009 - 2012
Biosurveillance Team, 2012

BioAssays Program Area Leader, Bioscience Division and Center for Homeland Security, Los Alamos National Laboratory, 2003 – 2006

Deputy Center Leader, Center for Human Genome Studies, Los Alamos National Laboratory, 1997 - 2002

Functional Genomics Thrust Leader, Bioscience Division, Los Alamos National Laboratory, 1999 – 2001

Staff Member, Genomics Group, Life Sciences Division and Center for Human Genome Studies, Los Alamos National Laboratory, 1989 - 1997

 

Professional Societies

HUGO, Human Genome Organization (elected member)

American Society of Human Genetics

American Association for the Advancement of Science

 

Awards

Distinguished Performance Small Team Award for Biodefense Informatics Team, Los Alamos National Laboratory, 2010

DOE Joint Genome Institute Achievement Award, 2000

Small Team Achievement Award, Los Alamos National Laboratory, 1997

Individual Achievement Award 1996 Los Alamos National Laboratory Distinguished Performance Team Award: Human Genome Project Team, Los Alamos National Laboratory, 1996

Hereditary Disease Foundation Postdoctoral Fellowship, 1988 - 1989

Public Health Service, National Research Service Award, National Cancer Institute Postdoctoral Trainee, 1987 - 1988

Public Health Service, National Research Service Award, Environmental Pathology Predoctoral Trainee, 1980 - 1985

 

Patents

US 6627745.  Pyrin gene and mutants thereof, which cause familial Mediterranean fever.  Kastner, Daniel L.; Aksentijevichh, Ivona; Centola, Michael; Deng, Zuoming; Sood, Ramen; Collins, Francis S.; Blake, Trevor; Liu, P. Paul; Fischel-Ghodsian, Nathan; Gumucio, Deborah L.; Richards, Robert I.; Ricke, Darrell O.; Doggett, Norman A.; Pras, Mordechai.  Official Gazette of the United States Patent and Trademark Office Patents ; Sep. 30 2003; v.1274, no.5

 

Publications

Nagy A, Steinbruck A, Gao J, Thoma J, Doggett N, Hollingsworth JA, and Iyer R. Comprehensive analysis of the effects of CdSe quantum dot size, surface charge, and functionalization on primary human lung cells. ACS Nano. 6(6):4748-62 (2012).

Smith TJ, Hill KK, Foley BT, Detter JC, Munk AC, Bruce DC, Doggett NA, Smith LA, Marks JD, Xie G, and Brettin TS. Analysis of the neurotoxin complex genes in Clostridium botulinum subtype A1-A4 and B1 strains – BoNT/A3 BoNT/A4 and BoNT/B1 clusters are located within plasmids. PLoS ONE 2(12): e1271 (2007).

Challacombe JF, Altherr MR, Xie G, Bhotika SS, Brown N, Bruce D, Campbell CS, Campbell ML, Chen J, Chertkov O, Cleland C, Dimitrijevic M, Doggett NA, Fawcett JJ, Glavina T, Goodwin LA, Green LD, Han CS, Hill KK, Hitchcock P, Jackson PJ, Keim P, Kewalramani AR, Longmire J, Lucas S, Malfatti S, Martinez D, McMurry K, Meincke LJ, Misra M, Moseman BL, Mundt M, Munk AC, Okinaka RT, Parson-Quintana B, Reilly LP, Richardson P, Robinson DL, Rubin E, Saunders E, Tapia R, Tesmer JG, Thayer N, Thompson LS, Tice H, Ticknor LO, Wills PL, Gilna P, and Brettin TS. The complete genome sequence of Bacillus thuringiensis Al Hakam. J. Bacteriol. 189:3680-3681 (2007).

Linnemann AK, Platts AE, Doggett N, Bode J. and Krawetz SA. Genome-wide identification of nuclear matrix attachment regions: An analysis of methods. Biochem Soc Trans. 35:612-617 (2007).

Cohen SM, Furey TS, Doggett NA, and Kaufman DG. Genome-wide sequence and functional analysis of early replicating DNA in normal human fibroblasts. BMC Genomics 7:301 (2006).

Doggett NA, Xie G, Meincke LJ, Sutherland RD, Mundt MO, Berbari NS, Davy BE, Robinson ML, Rudd MK, Weber JL, Stallings RL, and Han C. A 360 Kb interchromosomal duplication of the Human HYDIN locus. Genomics 88:762-771 (2006).

Han S, Xie G, Challacombe JF, Altherr MR, Bhotika SS, Bruce D, Campbell CS, Campbell ML, Chen J, Chertkov O, Cleland C, Dimitrijevic M, Doggett NA, Fawcett JJ, Glavina T, Goodwin LA, Hill KK, Hitchcock P, Jackson PJ, Keim P, Kewalramani AR, Longmire J, Lucas S, Malfatti S, McMurry K, Meincke LJ, Misra M, Moseman BL, Mundt M, ChristineMunk A, Okinaka RT, Parson-Quintana B, Reilly LP, Richardson P, Robinson DL, Rubin E, Saunders E, Tapia R, Tesmer JG, Thayer N, Thompson LS, Tice H, Ticknor LO, Wills PL, Brettin TS, and Gilna P. Pathogenomic sequence analysis of B. cereus and B. thuringiensis isolates closely related to Bacillus anthracis. J. Bacteriol. 188:3382-3390 (2006).

Yi W, Wu X, Lee T-H, Doggett NA, and Her C. Two variants of MutS homolog hMSH5: Prevalence in humans and effects on protein interaction. Biochemical and Biophysical Research Communications 332:524–532 (2005).

Martin J, Han C, Gordon LA, Terry A, Prabhakar S, She X, Xie G, Hellsten U, Chan YM, Altherr M, Couronne O, Aerts A, Bajorek E, Black S, Blumer H, Branscomb E, Brown NC, Bruno WJ, Buckingham JM, Callen DF, Campbell CS, Campbell ML, Campbell EW, Caoile CC, Challacombe JF, Chasteen LA, Chertkov O, Chi HC, Christensen M, Clark LM, Cohn JD, Denys M, Detter JC, Dickson M, Dimitrijevic-Bussod M, Escobar J, Fawcett JJ, Flowers D, Fotopulos D, Glavina T, Gomez M, Gonzales E, Goodstein D, Goodwin LA, Grady DL, Grigoriev I, Groza M, Hammon N, Hawkins T, Haydu L, Hildebrand CE, Huang W, Israni S, Jett J, Jewett PB, Kadner K, Kimball H, Kobayashi A, Krawczyk M-C, Leyba T, Longmire JL, Lopez F, Lou Y, Lowry S, Ludeman T, Manohar CF, Mark GA, McMurray KL, Meincke LJ, Morgan J, Moyzis RK, Mundt MO, Munk AC, Nandkeshwar RD, Pitluck S, Pollard M, Predki P, Parson-Quintana B, Ramirez L, Rash S, Retterer J, Ricke DO, Robinson DL, Rodriguez A, Salamov A, Saunders EH, Scott D, Shough T, Stallings RL, Stalvey M, Sutherland RD, Tapia R, Tesmer JG, Thayer N, Thompson LS, Tice H, Torney DC, Tran-Gyamfi M, Tsai M, Ulanovsky LE, Ustaszewska A, Vo N, White PS, Williams AL, Wills PL, Wu J-R, Wu K, Yang J, DeJong P, Bruce D, Doggett NA, Deaven L, Schmutz J, Grimwood J, Richardson P, Rokhsar DS, Eichler EE, Gilna P, Lucas SM, Myers RM, Rubin EM, and Pennacchio LA. The sequence and analysis of duplication-rich human chromosome 16. Nature 432:988-994 (2004). 90.

International Human Genome Sequencing Consortium (Author list of >6000 provided in supplementary information link to paper at wwwnaturecom/nature). Finishing the euchromatic sequence of the human genome. Nature 431:931-945 (2004).

Watson V, Doggett NA, Albertson DG, Andaya A, Chinnaiyan A, van Dekken H, Ginzinger D, Haqq C, Jain A, James K, Kamkar S, Kowbel D, Pinkel D, Schmitt L, Simko J, Volik S, Weinberg V, Paris PL. and Collins C. Integration of high resolution array comparative genomic hybridization analysis of chromosome 16q with expression array data refines common regions of loss at 16q23-qter and identifies underlying candidate tumor suppressor genes in prostate cancer. Oncogene 23:3487-3494 (2004).

So C-K, Nie Y, Song Y, Yang G-Y, Chen S, Wei C, Wang L-D, Doggett NA, and Yang C-S. Loss of heterozygosity and internal tandem duplication mutations of the CBP gene are frequent events in human esophageal squamous cell carcinoma. Clinical Cancer Research 10:19-27 (2004).

Dehal P, Satou Y, Campbell RK, Chapman J, Degnan B, De Tomaso A, Davidson B, Di Gregorio A, Gelpke M, Goodstein DM, Harafuji N, Hastings KEM, Ho I, Hotta K, HuangW, Kawashima T, Lemaire P, Martinez D, Meinertzhagen IA, Necula S, Nonaka M, Putnam N, Rash S, Saiga H, Satake M, Terry A, Yamada L, Wang H-G, Awazu S, Azumi K, Boore J, Branno M, Chin-bow S, DeSantis R, Doyle S, Francino P, Keys DN, Haga S, Hayashi H, Hino K, Imai KS, Inaba K, Kano S, Kobayashi K, Kobayashi M, Lee B-I, Makabe KW, Manohar C, Matassi G, Medina M, Mochizuki Y, Mount S, Morishita T, Miura S, Nakayama A, Nishizaka S, Nomoto H, Ohta F, Oishi K, Rigoutsos I, Sano M, Sasaki A, Sasakura Y, Shoguchi E, Shin-i T, Spagnuolo A, Stainier D, Suzuki MM, Tassy O, Takatori N, Tokuoka M, Yagi K, Yoshizaki F, Wada S, Zhang C, Hyatt PD, Larimer F, Detter C, Doggett N, Glavina T, Hawkins T, Richardson P, Lucas S, Kohara Y, Levine M, Satoh N, and Rokhsar DS. The draft genome of Ciona intestinalis: Insights into chordate and vertebrate origins. Science 298:2157-2167 (2002).

Powell J, Gardner AE, Bais AJ, Hinze S, Kotchekova M, Whitmore S, Crawford J, Spendlove H, Doggett NA, Sutherland GR, Callen DF, and Kremmidiotis G. Sequencing transcript identification and quantitative gene expression profiling in the breast cancer loss of heterozygosity region 16q24.3 reveals three potential tumour suppressor genes. Genomics 80:303-310 (2002).

Aparicio S, Chapman J, Stupka E, Putnam N, Chia J-M, Dehal P, Christoffels A, Rash S, Hoon S, Smit A, Gelpke MDS, Roach J, Oh T, Ho IY, Wong M, Detter C, Verhoef F, Predki P, Tay A, Lucas S, Richardson P, Smith SF, Clark MS, Edwards YJK, Doggett N, Aharkikh A, Tavtigian SV, Pruss D, Barnstead M, Evans C, Baden H, Powell J, Glusman G, Rowen L, Hood L, Tan YH, Elgar G, Hawkins T, Venkatesh B, Rokhsar D, and Brenner S. Whole-genome shotgun assembly and analysis of the genome of fugu rubripes. Science 297:1301-1310 (2002).

Abdi FA, Mundt M, Doggett N, Bradbury EM, and Chen X. Validation of DNA Sequences using mass spectrometry coupled with nucleoside mass tagging. Genome Research 12:1135-1141 (2002).

Abdi F, Bradbury EM, Doggett N, and Chen X. Rapid characterization of DNA oligomers and identification of single nucleotide polymorphisms using nucleotide-specific mass tags. Nucleic Acids Research 29:e61 (2001).

Han CS, Buckingham J, Meincke LJ, and Doggett NA. Vector for high-throughput sequencing: construction and preparation with cyclic cut-ligation. Biotechniques 30:1208-1211 (2001).

Daniels RJ, Peden JF, Lloyd CR, Horsley SW, Clark K, Tufarelli C, Kearney L, Buckle VJ, Doggett NA, Flint J, and Higgs DR. Sequence structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16. Human Molecular Genetics 10:339-352 (2001).

International Human Genome Sequencing Consortium: Lander ES, Linton LM, Birren B, Nusbaum C, Zody MC, Baldwin J, Devon K, Dewar K, Doyle M, Fitzhugh W, Funke R, Gage D, Harris K, Heaford A, Howland J, Kann L, Lehoczky J, Levine R, McEwan P, McKernan K, Meldrim J, Mesirov JP, Miranda C, Morris W, Naylor J, Raymond C, Rosetti M, Santos R, Sheridan A, Sougnez C, Stange-Thomann N, Stojanovic N, Subramnanian A, Wyman D, Rogers J, Sulston J, Ainscough R, Beck S, Bentley D, Burton J, Clee C, Carter N, Coulson A, Deadman R, Deloukas P, Dunham A, Dunham I, Durbin R, French L, Grafham D, Gregory S, Hubbard T, Humphray S, Hunt A, Jones M, Lloyd C, McMurray A, Matthews L, Mercer S, Milne S, Mullikin JC, Mungall A, Plumb R, Ross M, Shownkeen R, Sims S, Waterston RH, Wilson RK, Hillier LW, McPherson JD, Marra MA, Mardis ER, Fulton LA, Chinwalla AT, Pepin KH, Gish WR, Chissoe SL, Wendl MC, Delehaunty KD, Miner TL, Delehaunty A, Kramer JB, Cook LL, Fulton RS, Johnson DL, Minx PJ, Clifton SW, Hawkins T, Branscomb E, Predki P, Richardson P, Wenning S, Slezak T, Doggett N, Cheng J-F, Olsen A, Lucas S, Elkin C, Uberbacher E, Frazier M, Gibbs RA, Muzny DM, Scherer SE, Bouck JB, Sodergren EJ, Worley KC, Rives CM, Gorrell JH, Metsker ML, Naylor SL, Kucherlapati RS, Nelson DL, Weinstock GM, Sakaki Y, Fujiyama A, Hattori M, Yada T, Toyoda A, Itoh T, Kawagoe C, Watanabe H, Totoki Y, Taylor T, Weissenbach J, Heilig R, Saurin W, Artiguenave F, Brottier P, Bruls T, Pelletier E, Robert C, Wincker P, Smith DR, Doucette-Stamm L, Rubenfield M, Weinstock K, Lee HM, Dubois J, Rosenthal A, Platzer M, Nyakatura G, Taudien S, Rump A, Yang H, Yu J, Wang JI, Huang G, Gu J, Hood L, Rowen L, Madan A, Qin S, Davis RW, Federspiel NA, Abola AP, Proctor MJ, Myers RM, Schmutz J, Dickson M, Grimwood J, Cox DR, Olson MV, Kaul R, Raymond C, Shimizu N, Kawasaki K, Minoshima S, Evans GA, Athanasiou M, Schultz R, Roe BA, Chen F, Pan H, Ramser J, Lehrach H, Reinhardt R, McCombie WR, De la Bastide M, Dedhia N, Blöcker H, Hornischer K, Nordsiek G, Agarwala R, Aravind L, Bailey JA, Bateman A, Batzouglou S, Birney E, Bork P, Brown DG, Burge CB, Cerutti L, Chen H, Church D, Clamp M, Copley RR, Doerks T, Eddy SR, Eichler EE, Furey TS, Galagan J, Gilbert JGR, Harmon C, Hayashizaki Y, Haussler D, Hermjakob H, Hokamp K, Jang W, Johnson LS, Jones TA, Kasif S, Kaspryzk A, Kennedy S, Kent WJ, Kitts P, Koonin EV, Korf I, Kulp D, Lancet D, Lowe TM, McLysaght A, Mikkelsen T, Moran JV, Mulder N, Pollara VJ, Ponting CP, Schuler G, Schultz J, Slater G, Smit AFA, Stupka E, Szustakowki J, Thierry-Mieg D, Thierry-Mieg J, Wagner L, Wallis J, Wheeler R, Williams A, Wolf YI, Wolfe KH, Yang S, Yeh R, Collins F, Guyer MS, Peterson J, Felsenfeld A, Wetterstrand KA, Patrinos A, and Morgan MJ. Initial sequencing and analysis of the human genome. Nature 409:860-921 (2001).

The International Human Genome Mapping Consortium: McPherson JD, Marra M, Hillier L, Waterston RH, Chinwalla A, Wallis J, Sekhon M, Wylie K, Mardis ER, Wilson RK, Fulton R, Kucaba TA, Wagner-McPherson C, Barbazuk WB, Gregory SG, Humphray SJ, French L, Evans RS, Bethel G, Whittaker A, Holden JL, McCann OT, Dunham A, Soderlund C, Scott CE, Bentley DR, Schuler G, Chen H, Jang W, Green ED, Idol JR, Maduro VVB, Montgomery KT, Lee E, Miller A, Emerling S, Kucherlapati R, Gibbs R, Scherer S, Gorrell JH, Sodergren E, Clerc-Blankenburg K, Tabor P, Naylor S, Garcia D, De Jong PJ, Catanese JJ, Nowak N, Osoegawa K, Qin S, Rowen L, Madan A, Dors M, Hood L, Trask B, Friedman C, Massa H, Cheung VG, Kirsch IR, Reid T, Yonescu R, Weissenbach J, Bruls T, Heilig R, Branscomb E, Olsen A, Doggett N, Cheng J-F, Hawkins T, Myers RM, Shang J, Ramirez L, Schmutz J, Velasquez O, Dixon K, Stone NE, Cox DR, Haussler D, Kent WJ, Furey T, Rogic S, Kennedy S, Jones S, Rosenthal A, Wen G, Schilhabel M, Gloeckner G, Nyakatura G, Siebert R, Schlegelberger B, Korebberg J, Chen X, Fujiyama A, Hattori M, Toyoda A, Yada T, Park H, Sakake Y, Shimizu N, Asakawa S, Kawasaki K, Sasaki T, Shintani A, Shimizu A, Shibuya K, Kudoh J, Minoshima S, Ramser J, Seranski P, Hoff C, Poustka A, Reinhardt R, and Lehrach H. A physical map of the human genome. Nature 409:934-941 (2001).

Yu A, Zhao C, Fan Y, Jang W, Mungall AJ, Deloukas P, Olsen A, Doggett NA, Ghebranious N, Broman KW, and WeberJL. Comparison of human genetic and sequence-based physical maps. Nature 409:951-953 (2001).

The BAC Resource Consortium: Cheung VG, Nowak N, Jang W, Kirsch IR, Zhao S, Chen X-N, Furey TS, Kim U-J, Kuo W-L, Olivier M, Conroy J, Kasprzyk A, Massa H, Yonescu R, Sait S, Thoreen C, Snijders A, Lemyre E, Bailer JA, Bruzel A, Burrill WD, Clegg SM, Collins S, Dhami P, Friedman C, Han CS, Herrick S, Lee J, Ligon AH, Lowry S, Morley M, Narasimhan S, Osoegawa K, Plajzer-Frick Z, Plajzer-Frick I, Quade BJ, Scott D, Sorotkin K, Thorpe AA, Gray JW, Hudson J, Pinkel D, Reid T, Rowen L, Shen-ong GL, Strausberg RL, Birney E, Callen DF, Cheng J-F, Cox DR, Doggett NA, Carter NP, Eichler EE, Haussler D, Korenberg JR, Morton CC, Albertson D, Schuler G, De Jong PJ, and Trask BJ. Integration of cytogenetic landmarks into the draft sequence of the human genome. Nature 409:953-958 (2001).

Her C, Wu XL, Bailey SM, and Doggett NA. Mouse MutS homolog 4 is predominantly expressed in testis and interacts with MutS homolog 5. Mammalian Genome 12:73-76 (2001).

Pollock DD, Eisen JA, Doggett NA, and Cummings MP. A Case for evolutionary genomics and the comprehensive examination of sequence biodiversity. Molecular Biology and Evolution 17:1776-1788 (2000).

Han CS, Jewett PB, Campbell ML, Meincke LJ, Tesmer JG, Mundt MO, Sutherland RD, Kim U-J, Deaven LL, and Doggett NA. Construction of a BAC contig map of chromosome 16q by two-dimensional overgo hybridization. Genome Research. 10:714-721 (2000).

Cai L, Struk B, Adams MD, Ji W, Haaf T, Kang H-L, Dho SH, Xu X, Ringpfeil F, Nancarrow J, Zäch S, Schaen L, Stumm M, Niu T, Chung J, Lunze K, Verrecchia B, Goldsmith LA, Viljoen D, Figuera LE, Fuchs W, Lebwohl M, Uitto J, Richards R, Hohl D, Ramesar R, Callen DF, Kim U-J, Doggett NA, Neldner KH, and Lindpainter K. A 500 Kb region on chromosome 16p13.1 contains the pseudoxanthoma elasticum locus: High resolution mapping and genomic structure. Journal of Molecular Medicine 78:36-46 (2000).

Brylawski BP, Cohen SM, Longmire JL, Doggett NA, Cordeiro-Stone M, and Kaufman DG. Construction and characterization of cosmid libraries of DNA replicated very early in the S phase of normal human fibroblasts. Journal of Cellular Biochemistry 78:509-517 (2000).

Le Saux O, Urban Z, Göring HHH, CsisZar K, Pope FM, Richards A, Pasquali-Ronchetti I, Terry S, Bercovitch L, Lebwohl MG, Breuning M, vn der Berg P, Kornet L, Doggett N, Ott J, de Jong PTVM, Bergen AAB. and Boyd CD. Pseudoxanthoma elasticum maps to an 820-kb region of the p131 region of chromosome 16. Genomics 62:1-10 (1999) and Errata in Genomics 63:439 (2000).

Her C, Wu X, Wan W, and Doggett NA. Identification and characterization of the mouse MutS homologue 5: Msh5. Mammalian Genome 10:1054-1061 (1999).

Cao Y, Kang HL, Xu X, Wang M, Dho SH, RyulHuh J, Lee B-J, Kalush F, Bocskai D, Ding Y, Tesmer JG, Lee J, Moon E, Jurecic V, Baldini A, Weier H-U, Doggett NA, Simon MI, Adams MD, and Kim U-J. A 12 Mbp complete coverage BAC contig map in human chromosome 16p13.1-11.2. Genome Research 9:763-774 (1999).

Crawford J, Ianzano L, Savino M, Whitmore S, CletonJansen A-M, Settasatian C, dApolito M, Seshadri R, Pronk JC, Auerbach AD, Verlander PC, Mathew CG, Tipping AJ, Doggett NA, Zelante L, Callen DF, Savoia A. The PISSLRE gene: Structure exon skipping and exclusion as tumor suppressor in breast cancer. Genomics 56:90-97 (1999).

Centola M, Chen XG, Sood R, Deng ZM, Aksentijevich I, Blake T, Ricke DO, Chen X, Wood G, Zaks N, Richards N, Krizman D, Mansfield E, Apostolou S, Liu JM, Sharfran N, Vendula A, Hamon M, Cercek A, Kahan T, Gumucio D, Callen DF, Richards RI, Moyzis RK, Doggett NA, Collins FS, Liu PP, Fischel-Ghodsian N, and Kastner DL. Construction of an ~700-kb transcript map around the familial Mediterranean fever locus on human chromosome 16p13.3. Genome Research 8:1172-1191 (1998).

Greenham JA, Adams MD, Doggett NA, and Mole SA. Elucidation of the exon-intron structure of the human protein kinase C beta gene (PRKCB). Human Genetics 103:483-487 (1998).

Kramer JA, Adams MD, Singh GB, Doggett NA, and Krawetz SA. Extended analysis of the region encompassing the PRM1-PRM2-TNP2 domain: Genomic organization evolution and gene identification. Journal of Experimental Zoology 282:245-253 (1998).

Kouprina N, Campbell M, Graves J, Campbell E, Meincke L, Tesmer J, Grady DL, Doggett NA, Moyzis RK, Deaven LL, and Larionov V. Construction of human chromosome 16- and 5-specific circular YAC/BAC libraries by in-vivo recombination in yeast (TAR cloning). Genomics 53:21-28 (1998).

Whitmore SA, Settasatian C, Crawford J, Lower KM, McCallum B, Seshadri R, Cornelisse GJ, Moerland EW, Cleton-Jansen A-M, Tipping AJ, Mathew CG, Savnio M, Savoia A, Verlander P, Auerbach AD, Vanberkel C, Pronk JC, Doggett NA, and Callen DF. Characterization and screening for mutations of the growth-arrest-specific-11 (GAS11) and C16ORF3 genes at 16q24.3 in breast cancer. Genomics 52:325-331 (1998).

Her C and Doggett NA. Cloning structural characterization and chromosome localization of the human ortholog of Saccharomyces cerevisiae MSH5 gene. Genomics 52:50-61 (1998).

Centra M, Memeo E, d'Apolito M, Savino M, Ianzano L, Notarangelo A, Liu JM, Doggett NA, Zelante L, and Savoia A. Fine exon-intron structure of the Fanconi anemia group A (FAA) gene and characterization of two genomic deletions. Genomics 51:463-467 (1998).

Kuss BJ, O'Neil GM, Eyre H, Doggett NA, Callen DF, and Davey RA. ARA a novel ABC transporter is located at 16p13.1 is deleted in inv(16) leukaemias and is shown to be expressed in primative hematapoietic precursors. Genomics 51:455-458 (1998).

Whitmore SA, Crawford J, Apostolou S, Eyre H, Baker E, Lower KM, Settasatian C, Goldup S, Seshadri R, Gibson RA, Mathew CG, Cleton-Jansen A-M, Savoia A, Pronk JC, Auerbach AD, Doggett NA, Sutherland GR, and Callen DF. Construction of a high-resolution physical and transcription map of chromosome 16q24.3: A region of frequent loss of heterozygosity in sporadic breast cancer. Genomics 50:1-8 (1998).

Filippova GN, Lindblom A, Meincke LJ, Klenova EM, Neiman PE, Collins SJ, Doggett NA, and Lobanenkov VV. A widely expressed transcription factor with multiple DNA-sequence specificity CTCF is localized at chromosome segment 16q22.1 within one of the smallest regions of overlap for common deletions in breast and prostate cancers. Genes Chromosomes and Cancer 22:26-36 (1998). 57. Hiraguri S, Godfrey T, Nakamura H, Graff J, Collins C, Shayesteh L, Doggett N, Johnson K, Wheelock M, Herman J, Baylin S, Pinkel D, and Gray J. Mechanisms of inactivation of E-cadherin in breast cancer cell lines. Cancer Research. 58:1972-1977 (1998).

Kramer JA, Adams MD, Singh GB, Doggett NA, and Krawetz SA. A matrix associated region localizes the human SOCS-1 gene to chromosome 16p13.13. Somatic Cell and Molecular Genetics 24:131-133 (1998).

Levran O, Doggett NA, and Auerbach AD. Identification of Alu mediated deletions in patients with Fanconi anemia. Human Mutation 12:145-152 (1998).

Schollen E, Pardon E, Heykants L, Renard J, Doggett NA, Callen DF, Cassiman J-J, and Matthijs G. Comparative analysis of the phosphomannomutase genes PMM1 PMM2 and PMM2psi: The sequence variation in the processed pseudogene is a reflection of the mutations found in the functional gene. Human Molecular Genetics 7:157-164 (1998).

Balow Jr, JE, Shelton DA, Orsborn A, Mangelsdorf M, Aksentijevich I, Blake T, Sood R, Gardner D, Liu R, Pras E, Levy EN, Centola M, Deng ZM, Zaks N, Wood G, Chen XG, Richards N, Shohat M, Livneh A, Pras M, Doggett NA, Collins FS, Liu PP, Rotter JI, Fischel-Ghodsian N, Gumucio D, Richards RI, and Kastner DL. A high resolution genetic map of the familial Mediterranean fever candidate region allows identification of haplotype-sharing among ethnic groups. Genomics 44:280-291 (1997).

The International FMF Consortium: Aksentijevich I, Centola M, Deng Z, Sood R, Balow Jr, JE, Wood G, Zaks N, Mansfield E, Raben N, Eisberg S, Pras E, Pras M, and Kastner DL; Blake T, Baxevanis A, Collins FS, and Liu PP; Chen X, Shohat M, Rotter JI, and Fischel-Ghodsian N; Richards N, Shelton DA, and Gumucio DL; Yokoyama Y, Mangelsdorf M, Orsborn A, and Richards RI; Ricke DO, Buckingham JM, Moyzis RK, Deaven LL, and Doggett NA. Ancient missense mutations in a new member of the RoREt gene family cause familial Mediterranean fever. Cell 90:797-807 (1997).

Rowley JD, Reshmi S, Sobulo O, Musvee T, Anastasi J, Raimondi S, Schneider NR, Barredo JC, Schlegelberger B, Behm F, Doggett NA, Borrow J, and Zeleznik-Le N. All patients with the t(11;16)(q23;p13.3) which involves MLL and CBP have treatment-related hematological disorders. Blood 90:535-541 (1997).

Sobulo OM, Borrow J, Tomek R, Reshmi S, Harden A, Schlegelberger B, Housman D, Doggett NA, Rowley JD, and Zeleznik-Le N. Mll is fused to CBP a histone acetyltransferase in therapy-related acute myeloid leukaemia with a t(11;16)(q23;p13.3). Proc. Natl. Acad. Sci. USA. 94:8732-8737 (1997).

Eichler EE, Budarf M, Rocchi M, Deaven LL, Doggett NA, Baldini A, Nelson DL, and Mohrenweiser HW. Interchromosomal duplications of the Adrenoleukodystrophy locus: A phenomenon of pericentromeric plasticity. Human Molecular Genetics 6:991-1002 (1997).

Giles RH, Petrij F, Dauwerse HG, den Hollander AI, Lushnikova T, van Ommen G-J, Goodman RH, Deaven LL, Doggett NA, Peters DJM, and Breuning MH. Construction of a 12 Mb contig surrounding and molecular analysis of the human CREB-binding protein (CBP) gene on Chromosome 16p13.3. Genomics 42:96-114 (1997).

Sood R, Blake T, Aksentijevich I, Wood G, Chen X, Gardner D, Shelton DA, Mangelsdorf M, Orsborn A, Pras E, Balow Jr, JE, Centola M, Deng Z, Zaks N, Chen X, Richards N, Fischel-Ghodsian N, Rotter JI, Pras M, Shohat M, Deaven LL, Gumucio DL, Callen DF, Richards RI, Collins FS, Liu P, Kastner DL, and Doggett NA. Construction of a 1-Mb restriction-mapped cosmid contig containing the candidate region for the familial Mediterranean fever locus (MEFV) on 16p13.3. Genomics 42:83-95 (1997).

Mitchison HM, Taschner PEM, Kremmidiotis G, Callen DF, Doggett NA, Lerner TJ, Janes RB, Wallace BA, Munooe PB, O'Rawe AM, Gardiner RM, and Mole SE. Structure of the CLN3 gene and predicted structure location and function of the CLN3 protein. Neuropaediatrics 28:12-14 (1997).

Spicer AP, Seldin MF, Olsen A, Brown N, Wells DE, Doggett NA, Itano N, Kimata K, and McDonald JA. Chromosomal localization of the human and mouse hyaluronan synthase genes. Genomics 41:493-497 (1997).

Ianzano L, d'Apolito M, Centra M, Savino M, Levran O, Auerbach AD, Clenton-Jansen A-M, Doggett NA, Pronk J, Tipping AJ, Gibson RA, Mathew CG, Whitmore SA, Apostolou S, Callen DF, Zelante L, and Savoia A. The genomic organization of the Fanconi anaemia group A (FAA) gene. Genomics 41:309-314 (1997).

Mitchison HM, Munroe PB, O'Rawe AM, Taschner PEM, de Vos N, Kremmidiotis G, Lensink I, Munk CA, D'Arigo KL, Anderson JW, Lerner TJ, Moyzis RK, Callen DF, Breuning MH, Doggett NA, Gardiner RM, and Mole SE. Genomic structure and complete nucleotide sequence of the Batten disease gene CLN3. Genomics 40:346-350 (1997).

Flint J, Thomas K, Micklem G, Raynham H, Clark K, Doggett NA, King A, and Higgs DR. The relationship between chromosome structure and function at a human telomeric region. Nature Genetics 15:252-257 (1997).

Yu S, Mangelsdorf M, Duncan H, Hobson L, Baker E, Eyre H, Lapsys N, Lane S, LePaslier D, Doggett NA, Sutherland GR, and Richards RI. Distamycin A - sensitive chromosomal fragile site FRA16B is an amplified 33 base pair AT-rich minisatellite repeat. Cell 88:367-374 (1997).

The Fanconi anaemia/Breast Cancer Consortium: Apostolou S, Whitmore SA, Crawford J, Lennon G, Sutherland GR, and Callen DF; Ianzano L, Savino M, D'Apolito M, Notarangelo A, Meneo E, Piemontese MR, Zelante L, and Savoia A; Gibson RA, Tipping AJ, Morgan NV, Hassock S, Jansen S, de Ravel TJ, Van Berkel C, Pronk J, Easton DF, and Mathew CG; Clenton-Jansen A-M, Moerland EW, and Cornelisse CJ; Doggett NA, Deaven LL, and Moyzis RK. Positional cloning of the Fanconi anaemia group A gene. Nature Genetics 14:324-328 (1996).

Thomas CP, Doggett NA, Fisher R, and Stokes JB. Genomic organization and the 5' flanking region of the gamma subunit of the human amiloride-sensitive epithelial channel. Journal of Biological Chemistry 271:26062-26066 (1996).

Eichler EE, Lu F, Shen Y, Antonucci R, Jurecic V, Doggett NA, Moyzis RK, Baldini A, Gibbs RA, and Nelson DL. Duplication of a gene-rich cluster between 16p11.1 and Xq28: A novel pericentromeric-directed mechanism for paralogous genome evolution. Human Molecular Genetics 5:899-912 (1996).

Dackowski WR, Connors TD, Bowe A, Stanton V, Housman D, Doggett NA, Landes GM, and Klinger KW. The region surrounding the PKD1 gene: A 700-kb P1 contig from a YAC-deficient interval. Genome Research 6:515-524 (1996).

Iyer GS, Krahe R, Goodwin LA, Doggett NA, Siciliano MJ, Funanage VL, and Proujansky R. Identification of a testis-expressed creatine transporter gene at 16p11.2 and confirmation of the X-linked locus to Xq28. Genomics 34:143-146 (1996).

Doggett NA, Goodwin LA, Tesmer JG, Meincke LJ, Bruce DC, Clark LM, Altherr MR, Ford AA, Chi H-C, Marrone BL, Longmire JL, Lane SA, Whitmore SA, Lowenstein MG, Sutherland RD, Mundt MO, Knill EH, Bruno WJ, Macken CA, Torney DC, Wu JR, Griffith J, Sutherland GR, Deaven LL, Callen DF, and Moyzis RK. An integrated physical map of human chromosome 16. Nature 377:Suppl:335-365 (1995).

The International Batten Disease Consortium: Lerner TJ, Boustany R-MN, Anderson JW, D'Arigo KL, Schlumpf K, Buckler AJ, Gusella JF, and Haines JL; Kremmidiotis G, Lensink IL, Sutherland GR, and Callen DF; Taschner PEM, de Vos N, van Ommen G-JB. and Breuning MH; Doggett NA, Meincke LJ, Liu Z-Y, Goodwin LA, and Tesmer JG; Mitchison HM, O'Rawe A, Munroe PB, Järvelä IE, Gardiner RM, and Mole SE. Isolation of a novel gene underlying Batten disease CLN3. Cell 82:949-957 (1995).

Callen DF, Lane SA, Kozman H, Kremmidiotis G, Whitmore SA, Lowenstein M, Doggett NA, Kenmochi N, Page DC, Maglott DR, Nierman WC, Murakawa K, Berry R, Sikela JM, Houlgatte R, Auffray C, and Sutherland GR. Integration of transcript and genetic maps of chromosome 16 at near 1 Mb resolution: Demonstration of a 'hot-spot' for recombination at 16p12. Genomics 29:503-511 (1995).

Järvelä IE, Mitchison HM, O'Rawe AM, Taschner PEM, de Vos N, Lerner TJ, D'Arigo KL, Callen DF, Thompson AD, Knight M, Marrone BL, Mundt MO, Meincke L, Breuning MH, Gardiner RM, Doggett NA, and Mole SE. YAC and cosmid contigs spanning the Batten disease region (CLN3) at 16p12.1-p11.2. Genomics 29:478-489 (1995).

The AMERICAN PKD1 Consortium: Burn TC, Connors TD, Dackowski WR, Petry LR, Van Raay TJ, Millholland JM, Venet M, Miller G, Hakim RM, Landes GM, and Klinger KW; Qian F, Onuchic LF, Watnick T, and Germino GG; Doggett NA. Analysis of the genomic sequence for the autosomal dominant polycystic kidney diesase (PKD1) gene predicts the presence of a leucine-rich repeat. Human Molecular Genetics 4:575-582 (1995).

Taschner PEM, De Vos N, Thompson AD, Callen DF, Mole SE, Dooley TP, Doggett NA, Barth PG, and Breuning MH. Chromosome 16 microdeletion in a patient with juvenile neuronal ceroid lipofuscinosis (Batten disease). American Journal of Human Genetics 56:663-668 (1995).

Bruno WJ, Knill E, Balding DJ, Bruce DC, Doggett NA, Sawhill WW, Stallings RL, Whittaker CC, and Torney DC. Efficient pooling designs for library screening. Genomics 26:21-30 (1995).

Järvelä IE, Mitchison HM, Callen DF, Lerner TJ, Doggett NA, Taschner PEM, Gardiner RM, and Mole SE. Physical map of the region containing the gene for Batten disease (CLN3). American Journal of Medical Genetics 57:316-319 (1995).

Lerner TJ, D'Arigo KL, Haines JL, Doggett NA, Taschner PEM, Buckler AJ, and the Batten Disease Consortium. Isolation of genes from the Batten candidate region using exon amplification. American Journal of Medical Genetics 57:320-323 (1995).

Dooley TP, Obermoeller RD, Probst P, Mole S, Doggett NA, Callen DF, and Siciliano M. Phenol Sulfotransferases: Candidate genes for Batten disease. American Journal of Medical Genetics 57:327-332 (1995).

Cleton-Jansen AM, Moerland HW, Callen DF, Doggett NA, Devilee P, and Cornelisse CJ. Mapping of the breast basic conserved gene (bbc1) to band 16q24.3. Cytogenetics and Cell Genetics 68:49-51 (1995).

Dooley TP, Mitchison HM, Munroe PB, Probst P, Neal M, Siciliano MJ, Deng Z, Doggett NA, Callen DF, Gardiner RM, and Mole SE. Mapping of two phenol sulphotransferase genes STP and STM to chromosome 16p: Candidate genes for Batten Disease. Biochem. Biophys. Res. Comm. 205:482-489 (1994).

Dooley TP, Probst P, Munroe PB, Mole SE, Liu Z and Doggett NA. Genomic organization of the human catecholamine-sulfating phenol sulfotransferase gene (STM). Biochem. Biophys. Res. Comm. 205:1325-1332 (1994).

Shen Y, Kozman HM, Thompson A, Phillips HA, Holman K, Nancarrow J, Lane S, Chen ZL, Apostolou S, Doggett NA, Callen DF, Mulley JC, Sutherland GR, and Richards RI. A PCR-based genetic linkage map of human chromosome 16. Genomics 22:68-76 (1994).

Okumura K, Stallings RL, Doggett NA, and Ward DC. In situ hybridization mapping of human chromosome 16: Evidence for a high frequency of repetitive DNA sequences. Cytogenetics and Cell Genetics 67:61-67 (1994).

Nancarrow JK, Kremer E, Baker E, Holman K, Eyre H, Doggett NA, Le Paslier D, Callen DF, Sutherland GR, and Richards RI. Implications of FRA16A structure for the mechanism of chromosomal fragile site genesis. Science 264:1938-1941 (1994).

Schultz EA, Callen DF, Doggett NA, Haines JL, and Lerner TJ. Microsatellite repeat polymorphism at the D16S366 locus. Human Molecular Genetics 3:1713 (1994).

Shen Y, Holman K, Doggett NA, Callen DF, Sutherland GR, and Richards RI. Dinucleotide repeat polymorphisms at the D16S525 D16S359 and D16S522 loci. Human Molecular Genetics 3:210 (1994).

Doggett NA, Callen DF, Cheng ZL, Moore S, Tesmer J, Duesing L, and Stallings RL. Identification and regional localization of a human IMP dehydrogenase-like locus (IMPDHL1) at 16p13.13. Genomics 18:687-689 (1993).

Shen Y, Holman K, Doggett NA, Callen DF, Sutherland GR, and Richards RI. Four dinucleotide repeat polymorphisms on human chromosome 16. Human Molecular Genetics 2:1745 (1993).

Shen Y, Holman K, Doggett NA, Callen DF, Sutherland GR, and Richards RI. Three dinucleotide repeat polymorphisms on human chromosome 16p13.11 - p13.3. Human Molecular Genetics 2:1506 (1993).

Shen Y, Holman K, Doggett NA, Callen DF, Sutherland GR, and Richards RI. Six dinucleotide repeat polymorphisms on human chromosome 16q12.1 - q24.1. Human Molecular Genetics 2:1505 (1993).

Shen Y, Holman K, Doggett NA, Callen DF, Sutherland GR, and Richards RI. Five dinucleotide repeat polymorphisms on human chromosome 16q24.2 - q24.3. Human Molecular Genetics 2:1504 (1993).

Mitchison H, Thompson AD, Mullley JC, Kozman HM, Richards RI, Callen DF, Stallings RL, Doggett NA, Attwood J, McKay TR, Sutherland GR, and Gardiner RM. Fine genetic mapping of the Batten disease locus (CLN3) by haplotype analysis and demonstration of allelic association with chromosome 16p microsatellite loci. Genomics 16:455-460 (1993).

Stallings RL, Whitmore SA, Doggett NA, and Callen D. F. Refined physical mapping of chromosome 16 low abundance repetitive DNA sequences. Cytogenetics and Cell Genetics 63:97-101 (1993).

Callen DF, Doggett NA, Stallings RL, Chen LZ, Whitmore SA, Lane SA, Nancarrow JK, Apostolou S, Thompson AD, Lapsys NM, Eyre HJ, Baker EG, Shen Y, Richards RI, Holman K, Phillips H. and Sutherland GR. High resolution cytogenetic-based physical map of human chromosome 16. Genomics 13:1178-1185 (1992).

Stallings RL, Doggett NA, Callen D, Apostolou S, Chen LZ, Nancarrow JK, Whitmore SA, Harris P, Michison H, Breuning M, Sarich J, Fickett J, Cinkosky M, Torney DC, Hildebrand CE. and Moyzis RK. Evaluation of a cosmid contig physical map of human chromosome 16. Genomics 13:1031-1039 (1992).

Stallings RL, Doggett NA, Okumura K, and Ward D. Chromosome 16 specific repetitive DNA sequences that map to chromosome regions known to undergo breakage/rearrange-ment in leukemia cells. Genomics 13:332-338 (1992).

Doggett NA, Smith CL, and Cantor CR. The effect of DNA concentration on electrophoretic mobility in pulsed field gels. Nucleic Acids Research 20:859-864 (1992).

Narayanswami S, Doggett NA, Hildebrand CE, Clark LM, and Hamkalo BA. Cytological and molecular characterization of centromeres in Mus domesticus and mus spretus. Mammalian Genome 2:186-194 (1992).

Stallings RL, Torney DC, Hildebrand CE, Longmire JL, Deaven LL, Jett JH, Doggett NA, and Moyzis RK. Physical mapping of human chromosomes by repetitive sequence fingerprinting. Proc. Natl. Acad. Sci. USA. 87:6218-6222 (1990).

Doggett NA, Chen J-F, Smith CL, and Cantor CR. The Huntington disease gene is most likely within 325 kb of the telomere of chromosome 4. Proc. Natl. Acad. Sci. USA. 86:10011-10014 (1989).

Doggett NA, Cordeiro-Stone M, Chae C-B, and Kaufman DG. Timing of proto-oncogene replication: A possible determinant of early S phase sensitivity of C3H 10T1/2 cells to transformation by chemical carcinogens. Molecular Carcinogenesis 1:41-49 (1988).

Doggett NA. The temporal order of replication of proto-oncogenes in synchronized C3H 10T1/2 cells. Thesis University of North Carolina (1986).

Doggett NA, and McKenzie WH. An analysis of the distribution and dose response of chromosome aberrations in human lymphocytes after in vitro exposure to 137-cesium gamma radiation. Radiat. Environ. Biophys. 22:33-51 (1983).