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Lawrence O. Ticknor

Email
Phone (505) 667-6055

Capabilities

  • Biosciences
  • Biological threat identification, characterization, detection/diagnosis,
  • Computational Physics and Applied Mathematics
  • Monte Carlo methods
  • Statistics
  • Nuclear Engineering and Technology
  • Safeguards
  • Weapons Science and Engineering
  • Stockpile stewardship

Expertise

Professional Experience

           

DNA sequence comparisons; Comparison of Microbe Populations; Neural Nets and Clustering; Data Mining; Sample Plan Development for Estimation of Variables in Engineered and Natural Environments; Modeling Growth in Biological Populations; Monte Carlo Simulation; Nonlinear modeling;  Measurement Quality Control;  Instrument Calibration;  Categorical data analysis; Multivariate data analysis; Linear Models; Variance Propagation; Probability Risk Assessments and Reliability.

Education

Master of Science in Statistics,  University of California, Davis, CA. June 1987. Coursework in Linear Models, Categorical Data Analysis, Multivariate Data, Statistical Computing.

 

Master of Science in Forestry. Duke University, Durham, NC. June 1982. Concentration on System Science: computer modeling of populations, with coursework in statistics, field forestry, and forest economics.  M.S. Thesis:  The Evolution of Avirulence in Host-Parasite Systems

 

Bachelor of Science in Botany and Environmental Studies. Grinnell College, Grinnell, IA., June 1979. Emphasis in botany and ecology with coursework in mathematics, physics, and chemistry preparatory to graduate study.

 

LANL Positions

Scientist, Statistics Group (CCS-6), 1989- current.

Work history includes: Sampling for genetic comparisons; DNA Fragment Length Analyses and Phylogenetic trees; Neural Networks for anomaly detection; Quality control of measurements; Data analysis of microbe populations under differing environments; Instrument calibration problems and minimum detection limits; Measurement uncertainty; Error Propagation in Systems; Spatial sampling and data analysis; Environmental restoration data analysis and sampling problems.

 

Professional Societies

American Statistical Association

 

Awards

2010 Distinguished Performance Award - BioWatch Assay Evaluation Team

 

Publications

Burr, Tom, Hamada, Michael S. , Ticknor, Larry , Sprinkle, James, "Hybrid Statistical Testing for Nuclear Material Accounting Data and/or Process Monitoring Data in Nuclear Safeguards", Energies, Vol.8, p.501-528, January 13, 2015.

Dabritz, Haydee A, Karen k. Hill, Jason R. Barash, Lawrence O. Ticknor, Charles H. Helma, Nir Dover, Jessica R. Payne, Stephen S. Arnon (2014), “Molecular Epidemiology of Infant Botulism in California and Elsewhere, 1976-2010.”  Journal of Infectious Diseases, 210(11): 1711-1722

Burr, Tom, Hamada, Michael S. , Ticknor, Larry , Weaver, Brian, "Model selection and change detection for a time-varying mean in process monitoring", NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT, Vol.751, p.79-87, JUL 1 2014.

Burr, Tom, Hamada, Michael S., Howell, John, Skurikhin, Misha, Ticknor, Larry ,Weaver, Brian, "Estimating Alarm Thresholds for Process Monitoring Data under Different Assumptions about the Data Generating Mechanism", Science and Technology of Nuclear Installations, p.705878, 2013.

Hill, K. K., Smith, T. J., Ticknor, L. O., Foley, B. T., Xie, G., "Genetic diversity between and within botulinum neurotoxin serotypes", Toxicon, Vol.68, p.60-61, JUN 15 2013.

Van Cuyk, S, Deshpande, A, Hollander, A, Franco, DO, Teclemariam, NP, Layshock, JA, Ticknor, LO, Brown, MJ, Omberg, KM, "Transport of Bacillus Thuringiensis var. Kurstaki from and Outdoor Release into Buildings" Pathways of Infiltration and a Raid Method to Identify Contaminated Buildings", BIOSECURITY AND BIOTERRORISM-BIODEFENSE STRATEGY PRACTICE AND SCIENCE, Vol.10, iss.2, p.215-227, JUN 2012.

Kuske, CR, Yeager, CM, Johnson, S, Ticknor, LO, Belnap, J, "Response and resilience of soil biocrust bacterial communities to chronic physical disturbance in arid shrublands", ISME JOURNAL, Vol.6, iss.4, p.886-897, APR 2012.

Macdonald, TE, Helma, CH, Shou, YL, Valdez, YE, Ticknor, LO, Foley, BT, Davis, SW, Hannett, GE, Kelly-Cirino, CD, Barash, JR, Arnon, S, Lindstrom, M, Korkeala, H, Smith, LA, Smith, TJ, Hill, KK, "Analysis of Clostridium botulinum Serotype E Strains by Using Multilocus Sequence Typing, Amplified Fragment Length Polymorphism, Variable-Number Tandem-Repeat Analysis, and Botulinum Neurotoxin Gene Sequencing", Applied and Environmental Microbiology, Vol.77, iss.24, p.8625-8634, DEC 2011.

Van Cuyk, S, Deshpande, A, Hollander, A, Duval, N, Ticknor, L, Layshock, J, Gallegos-Graves, L, Omberg, KM, "Persistence of Bacillus thuringiensis subsp Kurstaki in Urban Environments following Spraying", Applied and Environmental Microbiology, Vol.77, iss.22, p.7954-7961, NOV 2011.

Dunbar, J., Xie, G., Ticknor, L., Vilgalys, R., Zak, D., Schadt, C., Megonigal, P., Evans, D., Hungate, B., Eichorst, S., Rogers, Y., Gallegos-Graves, L., Silva, S., Bruce, D., Kuske, C., "Impacts of Multi-year, Elevated CO2 Conditions on Soil Bacterial Communities across Different Terrestrial Ecosystems", Abstracts of the General Meeting of the American Society for Microbiology, Vol.109, 2009.

Kuske, C., Xie, G., Dunbar, J., Ticknor, L., Vilgalys, R., Zak, D., Schadt, C., Megonigal, P., Evans, R. D., Hungate, B. A., Eichorst, S., Johnson, S., Rogers, Y., Gallegos-Graves, L., Silva, S., Bruce, D], "Impacts of Multi-year, Elevated CO2 Conditions on Soil Fungal Communities across Different Terrestrial Ecosystems", Abstracts of the General Meeting of the American Society for Microbiology, Vol.109, 2009.

Omberg, Kristin M., Van Cuyk, Sheila, Deshpande, Alina, Hollander, Attelia, Ticknor, Larry, White, P. Scott, "ENVR 48-Surface and bulk sampling to characterize the fate of Bacillus thuringiensis var. Kurstaki (Btk) in urban environments", Abstracts of Papers American Chemical Society, Vol.238, p.48-ENVR, AUG 16 2009.

Koppisch, AT, Dhungana, S, Hill, KK, Boukhalfa, H, Heine, HS, Colip, LA, Romero, RB, Shou, YL, Ticknor, LO, Marrone, BL, Hersman, LE, Iyer, S, Ruggiero, CE, "Petrobactin is produced by both pathogenic and non-pathogenic isolates of the Bacillus cereus group of bacteria", BIOMETALS, Vol.21, iss.5, p.581-589, OCT 2008.

West, DS, Frame, KJ, Thompson, J, Ticknor, LO, "Evaluation of a newly developed tritium calorimeter at Los Alamos National Laboratory", FUSION SCIENCE AND TECHNOLOGY, Vol.54, iss.1, p.178-181, JUL 2008.

Macdonald, TE, Helma, CH, Ticknor, LO, Jackson, PJ, Okinaka, RT, Smith, L, Smith, TJ, Hill, KK, "Differentiation of Clostridium botulinum serotype a strains by multiple-locus variable-number tandem-repeat analysis", APPLIED AND ENVIRONMENTAL MICROBIOLOGY, Vol.74, iss.3, p.875-882, FEB 2008.

Challacombe, JF * Altherr, MR * Xie, G * Bhotika, SS * Brown, N * Bruce, D * Campbell, CS * Campbell, ML * Chen, J * Chertkov, O * Cleland, C * Dimitrijevic, M * Doggett, NA * Fawcett, JJ * Glavina, T * Goodwin, LA * Green, LD * Han, CS * Hill, KK * Hitchcock, P * Jackson, PJ * Keim, P * Kewalramani, AR * Longmire, J * Lucas, S * Malfatti, S * Martinez, D * McMurry, K * Meincke, LJ * Misra, M * Moseman, BL * Mundt, M * Munk, AC * Okinaka, RT * Parson-Quintana, B * Reilly, LP * Richardson, P * Robinson, DL * Saunders, E * Tapia, R * Tesmer, JG * Thayer, N * Thompson, LS * Tice, H * Ticknor, LO * Wills, PL * Gilna, P * Brettin, TS], "The complete genome sequence of Bacillus thuringiensis Al Hakam", JOURNAL OF BACTERIOLOGY, Vol.189, iss.9, p.3680-3681, MAY 2007.

Hill, KK * Smith, TJ * Helma, CH * Ticknor, LO * Foley, BT * Svensson, RT * Brown, JL * Johnson, EA * Smith, LA * Okinaka, RT * Jackson, PJ * Marks, JD], "Genetic diversity among botulinum neurotoxin-producing clostridial strains", JOURNAL OF BACTERIOLOGY, Vol.189, iss.3, p.818-832, FEB 2007.

Han, CS * Xie, G * Challacombe, JF * Altherr, MR * Bhotika, SS * Bruce, D * Campbell, CS * Campbell, ML * Chen, J * Chertkov, O * Cleland, C * Dimitrijevic, M * Doggett, NA * Fawcett, JJ * Glavina, T * Goodwin, LA * Hill, KK * Hitchcock, P * Jackson, PJ * Keim, P * Kewalramani, AR * Longmire, J * Lucas, S * Malfatti, S * McMurry, K * Meincke, LJ * Misra, M * Moseman, BL * Mundt, M * Munk, AC * Okinaka, RT * Parson-Quintana, B * Reilly, LP * Richardson, P * Robinson, DL * Rubin, E * Saunders, E * Tapia, R * Tesmer, JG * Thayer, N * Thompson, LS * Tice, H * Ticknor, LO * Wills, PL * Brettin, TS * Gilna, P], "Pathogenomic sequence analysis of Bacillus cereus and Bacillus thuringiensis isolates closely related to Bacillus anthracis", JOURNAL OF BACTERIOLOGY, Vol.188, iss.9, p.3382-3390, MAY 2006.

Hoffmaster, AR * Hill, KK * Gee, JE * Marston, CK * De, BK * Popovic, T * Sue, D * Wilkins, PP * Avashia, SB * Drumgoole, R * Helma, CH * Ticknor, LO * Okinaka, RT * Jackson, PJ], "Characterization of Bacillus cereus isolates associated with fatal pneumonias: Strains are closely related to Bacillus anthracis and Harbor B-anthracis virulence genes", JOURNAL OF CLINICAL MICROBIOLOGY, Vol.44, iss.9, p.3352-3360, SEP 2006.

Hill, K.K., L. O. Ticknor, R.T. Okinaka, M. Asay, H. Blair, K.A. Bliss, M. Laker, P.E. Pardington, A. P. Richardson, M. Tonks, D.J. Beecher, J.J. Kemp, A.-B. Kolsto, A.C. Lee Wong, P. Keim, P.J. Jackson. (2004) Fluorescent Amplified Fragment Length Polymorphism Analysis of Bacillus anthracis, Bacillus cereus, and Bacillus thuringiensis Isolates. Applied and Env. Microbiology. 70:1068-1080.

Radnedge, L., P.G. Agron, K.K. Hill, P.J. Jackson, L. O. Ticknor, P. Keim, G.L. Andersen. ( 2003) Genome Differences That Distinguish Bacillus anthracis from Bacillus cereus and Bacillus thuringiensis. Applied and Env. Microbiology. 69:2755-2764.

Kuske, C.R., L. O. Ticknor, J.D. Busch, C.A. Gehring, and T.G Whitham. (2003) The pinyon rhizosphere, plant stress and hervivory affect the abundance of microbial decomposers in soils. Microbial Ecol. 45:340-352.

Toh, C.H., L. O. Ticknor, C. Downey, A. R. Giles, R. C. Paton, R. Wenstone. (2003) Early identification sepsis and mortality risks through simple, rapid clot-waveform analysis.  Intensive Care Medicine. 29:55-61

Toh, C.H., J. Samis, C. Downey, J. Walker, L. Becker, N. Brufatto, L. Tejidor, G. Jones, W. Houdijk, A. Giles, M. Koschinsky, L. O. Ticknor, R. C. Paton, R. Wenstone, M. Nesheim. (2002) The biphasic transmittance waveform in the APTT coagulation assay is due to the formation of Ca++-dependent complex of c-reactive protein with very low density lipoprotein and is a novel marker of impending disseminated intravascular coagulation. Blood, 100:7, 2522-2529.

Dunbar, J., S.M. Barns, L. O. Ticknor, and C.R. Kuske. (2002) Empirical and theoretical bacterial diversity in four Arizona soils. Appl. Environ. Microbiol. 68:3035-3035.

Kuske, C.R., L. O. Ticknor, M.E. Miller, J.M. Dunbar, J.A. Davis, S.M. Barns, and J. Belnap. (2002) Comparison of soil bacterial communities in rhizospheres of three plant species and the interspace of an arid grassland. Appl. Environ. Microbiol. 68:1854-1863.

Pannucci, J., R. Okinaka, E. Williams, R. Sabin, L. O. Ticknor, and C.R. Kuske. (2002) DNA sequence conservation between Bacillus anthracis pXO2 plasmid and closely related bacteria. BMC Genomics, 3:34.

Dunbar, J., L. O. Ticknor, and C.R. Kuske. (2001) Phylogenetic specificity, reproducibility, and a new method for analysis of 16S rDNA terminal restriction fragment profiles of bacterial communities. Appl. Environ.

Hersman, L. E,  J.H. Forsythe, L. O. Ticknor, P. A. Maurice. (2001)  Growth of P. mendocina on Fe(III) (hydro)oxides. Appl. Environ. Microbiol. 67:4448-4453.

Ticknor, L.O.,A.-B. Kolsto, K.K. Hill, P. Keim, M.T. Laker, M Tonks, and P.J. Jackson. (2001) Fluorescent Amplified Fragment Length Polymorphism Analysis of Norwegian Bacillus cereus and Bacillus thuringiensis Soil Isolates. Applied and Env. Microbiology. 67:4863-4873.

Howse, J. W., L. O. Ticknor, and K. R. Muske. (2001) Least squares estimation techniques for positions tracking of radioactive sources. Automatica, 37:1727-1737.

Dunbar, J., L. O. Ticknor, and C.R. Kuske. (2000) Assessment of microbial diversity in four Southwestern U.S. soils by 16S rDNA terminal restriction fragment (TRF) analysis. Appl. Environ. Microbiol. 66:2943-2950.

Kuske, C.R., L. O. Ticknor, L. Gurley, J. Valdez, M. Rice, and P.J. Jackson. (1994) Purification and characterization of three O-acetylserine sulfhydrylase isoenzymes from Datura innoxia. J. Biol. Chem. 269:6223-6232.