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Elizabeth Hong-Geller

Elizabeth Hong-Geller

Capabilities

  • Biosciences
  • Biosecurity
  • Pre-symptomatic diagnosis of infection,
  • Vaccines and therapeutics for infectious diseases
  • Pathogen studies
  • Biological threat identification, characterization, detection/diagnosis,
  • Biological countermeasure
  • Transcriptomics
  • Microbial biochemistry
  • Chemical Science
  • Biomarkers

Expertise

Host-pathogen interactions –  Mechanisms of pathogen virulence and host immunity

Therapeutics – Molecular strategies to defeat infectious disease

Cell and molecular biology – Advanced tools to investigate cellular behavior and physiology

Education

Ph.D, Molecular and Cell Biology, MIT, Cambridge, MA, 1991 - 1997

BA, Biochemistry, Columbia University, NY, NY, 1987 - 1991

 

LANL Positions

Team Leader, Host-Pathogen Biology, LANL, 2009 - current 

Staff Scientist, LANL, 2003 - current 

Co-Editor, HIV/SIV Vaccine Trials Database, 2006 - 2007

Post-doctoral Associate, LANL, 2000 - 2003    

 

Professional Societies

Editorial Review Board, Frontiers in Microbial Immunology, 2012 - current

 

Awards

Interview with Santa Fe New Mexican on Host-Pathogen research, 11/3/2012

Featured in Genetic Engineering and Biotechnology News, OMICs section “Embattled RNAi Technology Tries New Tack”, 1/15/2012

Los Alamos Award Program (LAAP) in Exceptional Mentoring, 2010 

LANL/S&T Institutional Research Grant, 2003 - 2005 

American Cancer Society Post-doctoral Fellowship, 1997 - 2000 

NIH Post-doctoral Fellowship – National Research Service Award, 1997 

Association for Women in Science (AWIS) Educational Foundation Award, 1997    

NIH Graduate Traineeship, 1991 - 1997

 

Patents

USA US 07576183 -  Structure-based receptor mimics targeted against bacterial superantigen toxins, Goutam Gupta, Elizabeth Hong-Geller, Patrick Shiflett, and Nancy Lehnert

 

Publications

Hong-Geller E. (2013) Small-RNA-mediated regulation of host-pathogen interactions. Virulence. In preparation.

Stubben CJ, Micheva-Viteva S, Shou Y, Dunbar JM, and Hong-Geller E. (2013) Differential expression of small RNAs from Burkholderia thailandensis in response to environmental and stressful growth conditions. In preparation.

Shepherd DP, Li N, Micheva-Viteva S, Munsky B, Hong-Geller E, and Werner J. (2013)  Counting small RNA in pathogenic bacteria. Submitted.

Micheva-Viteva S, Shou Y, Nowak-Lovato K, Rector KD, and Hong-Geller E.  (2013) c-KIT-EGR1 signaling is targeted by Yersinia during infection.  Submitted.

Nowak-Lovato K, Alexandrov LB, Banisadr A, Bauer AL, Bishop AR, Usheva A, Mu F, Hong-Geller E, Rasmussen K, Hlavacek WS, and Alexandrov BS. (2013) Binding of Nucleoid-associated Protein Fis to DNA is Regulated by DNA Breathing Dynamics. PLoS Comp. Biol. Jan;9(1):e1002881. doi: 10.1371/journal.pcbi.1002881.

Marti-Arbona R, Teshima M, Anderson PS, Nowak-Lovato K, Hong-Geller E, Unkefer C, and Unkefer P. (2012) Identification of new ligands for the methionine biosynthesis transcriptional regulator (MetJ) by FAC-MS.  J. Mol Microbiol Biotech. 22: 205-214.

Novak-Lovato K, Hickmott AJ, Maity, TS, Bulyk ML, Dunbar J, and Hong-Geller E. (2012) DNA binding site analysis of Burkholderia thailandensis response regulators. J. Microbiol. Methods. 90:46-52.

Taylor-McCabe, K, Shou, Y, and Hong-Geller, E. (2012) Effects of Bacillus anthracis hydrophobicity and induction of host cell death on sample collection from environmental surfaces. J. Gen. Appl. Microbiology. 58: 113-119.

Maity, TS, Close, DW, Valdez, YE, Nowak-Lovato, K, Marti-Arbona, R, Nguyen, TT, Unkefer, PJ, Hong-Geller, E, Bradbury, AR, and Dunbar, JM (2012) Discovery of DNA operators for TetR and MarR family transcription factors from Burkholderia xenovorans. Microbiology. 158: 571-82.

Hong-Geller, E., Valdez, Y., Shou, Y., Yoshida, T., Marrone, B., and Dunbar, J. (2010)  Evaluation of B. anthracis and Y. pestis sample collection from nonporous surfaces by quantitative real-time PCR. Lett. Appl. Microbiol. 50: 431-7.

Hong-Geller, E. and Micheva-Viteva, S. (2010) Functional gene discovery using RNA interference-based genomic screens to combat pathogen infection. Curr. Drug Discov. Technol. 7: 86-94.

Hong-Geller, E. (2009) A role for cell adhesion in beryllium-mediated lung disease. J. Occup. Environ. Hyg. 6: 727-731.

Lauer, S., Kunde, YA, Apodaca, TA, Goldstein, B., and Hong-Geller, E. (2009) Soluble MD2 increases TLR4 levels on the epithelial cell surface.  Cell. Immunol. 255: 8-16.

Rodriguez, S., Kunde, YA, McClesky, TM, and Hong-Geller, E. (2008) Upregulation of I-CAM1 in response to beryllium exposure in small airway epithelial cells. Toxicol. Lett. 179: 140-7.

Hong-Geller, E, Chaudhary, A. and Lauer, S. (2008) Targeting Toll-like receptor signaling pathways for design of novel immune therapeutics. Curr Drug Disc Tech. 5: 29-38.

Scott, BL., McCleskey, TM, Chaudhary, A., Hong-Geller, E, and Gnanakaran, S. (2008) The bioinorganic chemistry and associated immunology of chronic beryllium disease.  Chem. Commun. 25: 2837-47.

Hong-Geller, E., Pardington, P., Cary, R., Sauer, N., and Gupta, G. 2006. Chemokine regulation in response to beryllium exposure in human peripheral blood mononuclear and dendritic cells. Toxiciology. 218:216-28.

Hong-Geller, E., Molhoff, M. Shiflett, P.R., and Gupta, G. (2004) Design of chimeric receptor mimics with different TcRVb isoforms: type-specific inhibition of superantigen pathogenesis. J. Biol. Chem. 279:5676-5684.

Hong-Geller, E. and G. Gupta. 2003. Therapeutic approaches to superantigen-based diseases. J. Molec. Recog. 16:91-101.

Zhong, B., K. Jiang, D.L. Gilvary, P.K. Epling-Burnette, C. Ritchey, J. Liu, R.J. Jackson, E. Hong-Geller, and S. Wei. 2003. Human neutrophils utilize a Rac/Cdc42-dependent MAPK pathway to direct intracellular granule mobilization towards ingested microbial pathogens. Blood. 101:3240-3248.

Jiang, K., B. Zhong, B. Ritchey, D.L. Gilvary, E. Hong-Geller, S. Wei, and J.Y. Djeu. 2003. Regulation of AKT dependent cell survival by Syk and Rac. Blood. 101:236-44.

Jiang, K., Zhong, B., Gilvary, D.L., Corliss, B.C., Vivier, E., Hong-Geller, E., Wei, S. and J.Y. Djeu. 2002. Syk regulation of phosphoinositide 3-kinase-dependent NK cell function. J. Immun. 168:3155-64.

Hong-Geller, E., D.A. Holowka, R.P. Siraganian, B.A. Baird, and R.A. Cerione. 2001. Activation of PLCg1 by Cdc42/Rac during mast cell degranulation. Proc. Natl Acad Sci. 98:1154-1159.

Hong-Geller, E., K. Field, J. Apgar, R.P. Siraganian, B.A. Baird, and D.A. Holowka. 2000. Mutant RBL mast cells defective in FceR1 signaling and lipid raft biosynthesis are reconstituted by activated Rho-family GTPases. Mol. Biol. Cell. 11:3661-3673.

Hong-Geller, E., and R. Cerione. 2000. Cdc42 and Rac stimulate exocytosis of secretory vesicles by activating the IP3/calcium pathway in RBL-2H3 mast cells. J.Cell Biol. 148: 481-494.

Jiang, K., B. Zhong, D.L. Gilvary, B.C. Corliss, E. Hong-Geller, S. Wei, and J.Y. Djeu. 2000. Pivotal role of phosphoinositide-3 kinase in regulation of cytotoxicity in natural killer cells. Nature Immun. 1:419-425.

Hong, E., A.R. Davidson, and C.A. Kaiser. 1996. A pathway for targeting soluble misfolded proteins to the yeast vacuole. J.Cell Biol. 135:623-633.