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Los Alamos computational scientist wins 2016 Carcinogenesis Young Investigator Award

Ludmil Alexandrov is the winner of the 2016 Carcinogenesis Young Investigator Award.
July 11, 2016
Ludmil Alexandrov

Ludmil Alexandrov

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“Ludmil’s research uses large-scale computational screening and analysis to understand the mutational processes operating in human cancer and aging. This information has the potential to benefit the development of personalized medical healthcare,” said Alan Bishop.

LOS ALAMOS, N.M., July 11, 2016—Ludmil Alexandrov, of Los Alamos National Laboratory’s Theoretical Biology and Biophysics group, is the winner of the 2016 Carcinogenesis Young Investigator Award. Given biennially by the journal Carcinogenesis: Integrative Cancer Research, published by Oxford University Press, and the European Association for Cancer Research, the award recognizes a recent significant contribution to carcinogenesis research by an investigator under the age of 40.

“Ludmil’s research uses large-scale computational screening and analysis to understand the mutational processes operating in human cancer and aging. This information has the potential to benefit the development of personalized medical healthcare,” said Alan Bishop, principal associate director of the Laboratory’s Science, Technology and Engineering directorate. “Ludmil's work exemplifies the Lab's ability to help solve the nation's toughest challenges by applying innovative multidisciplinary science, technology and engineering to protect the nation and world.”

Alexandrov’s group is one of the few in the world that is devoted to understanding cancer causation and cancer prevention through mathematical modeling and computational analysis of genomics data. This research supports the Laboratory’s Information, Science, and Technology Science Pillar, which addresses emerging challenges in national security, societal prosperity and fundamental science.

Alexandrov was presented with his award at a ceremony in Manchester, U.K. on July 10.  His latest article Understanding mutagenesis through delineation of mutational signatures in human cancer is available here.

About the Carcinogenesis Journal

Carcinogenesis: Integrative Cancer Research is a multidisciplinary journal that brings together all the varied aspects of research that will ultimately lead to the prevention of cancer. The journal publishes papers that warrant prompt publication in the areas of biology, genetics and epigenetics, cancer biomarkers and molecular epidemiology, inflammation, microenvironment and carcinogenesis.

About Alexandrov

Alexandrov is an Oppenheimer Fellow in the Theoretical Biology and Biophysics group and the Center for Nonlinear Studies at the Laboratory. He earned his bachelor’s degree in computer science from Neumont University and received his master’s degree in computational biology and his doctoral degree in cancer genetics from the University of Cambridge.

He developed the first mathematical model describing signatures of mutational processes in human cancer as well as the first computational framework for extracting these signatures from next-generation sequencing data from cancer genomes. He then used this framework to map the mutational signatures in 7,042 cancer genomes, providing the first comprehensive map of the mutational signatures in human cancer. Alexandrov mapped the signatures of clock-like mutational processes operative in normal somatic cells and demonstrated that mutational signatures can be used for targeted cancer therapy.

Alexandrov has received numerous recognitions for his work on mutational signatures in human cancer. In 2014, Forbes magazine listed him as one of the 30 brightest stars under the age of 30 in the field of science and healthcare. In 2015, the American Society of Clinical Oncology highlighted his research as an important step forward in the fight against cancer. Alexandrov was also awarded the Weintraub Award by the Fred Hutchinson Cancer Center and the Prize for Young Scientists in Genomics and Proteomics by Science magazine & SciLifeLab.

About Los Alamos National Laboratory

Los Alamos National Laboratory, a multidisciplinary research institution engaged in strategic science on behalf of national security, is operated by Los Alamos National Security, LLC, a team composed of Bechtel National, the University of California, BWXT Government Group, and URS, an AECOM company, for the Department of Energy’s National Nuclear Security Administration.

Los Alamos enhances national security by ensuring the safety and reliability of the U.S. nuclear stockpile, developing technologies to reduce threats from weapons of mass destruction, and solving problems related to energy, environment, infrastructure, health, and global security concerns.


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